3-methyl-oct-7-en-2-one | 3664-61-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methyl-oct-7-en-2-one
• 英文别名: 3-Methyloct-7-en-2-one
• CAS: 3664-61-7
• 化学式: C₉H₁₆O
• 分子量: 140.225
• InChiKey: GYNMERYDVPDNCJ-UHFFFAOYSA-N

物化性质

• 沸点：
  182 °C
• 密度：
  0.826±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-methyl-oct-7-en-2-one 在 sodium hypoiodite 作用下， 生成 (1R*,2S*)1,2-Dimethylcyclopentanecarboxylic acid
  参考文献：
  名称：

  Rouessac,F. et al., Bulletin de la Societe Chimique de France, 1967, p. 818 - 822

  摘要：

  DOI：
• 作为产物：
  描述：

  2-acetyl-2-methyl-hept-6-enoic acid ethyl ester 在 2,6-二甲基吡啶 、 lithium iodide 作用下， 反应 20.0h， 以89%的产率得到3-methyl-oct-7-en-2-one
  参考文献：
  名称：

  On the mechanism of the intramolecular samarium Barbier reaction. Probes for formation of radical and organosamarium intermediates

  摘要：

  A new type of mechanistic probe for the intramolecular samarium Barbier reaction has been designed, and two different probe substrates have been investigated in detail. Remarkably, no unambiguous evidence could be obtained in favor of any of the obvious intermediates (free alkyl or alkoxy radicals, ketyls, organosamarium species) that are postulated for this reaction. Several possibilities for modified mechanisms are suggested. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00608-x

文献信息

• Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors
  申请人：Attenni Barbara

  公开号：US20090048228A1

  公开（公告）日：2009-02-19

  The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.

  本发明涉及以下式I的化合物：或其药用可接受的盐或互变异构体，这些化合物是组蛋白去乙酰化酶（HDAC）的抑制剂。本发明的化合物可用于治疗细胞增殖性疾病，包括癌症。此外，本发明的化合物还可用于治疗神经退行性疾病、精神分裂症和中风等其他疾病。
• Clemmensen Reduction. XI. Fragmentation Reactions of Some 3-Acetylcycloalkanones
  作者：KE Bailey、BR Davis

  DOI：10.1071/ch9951827

  日期：——

  Clemmensen reduction of a series of 3-acetylcycloalkanones yields, as the major product, an acyclic unsaturated ketone, the product of fragmentation. Some normal carbonyl-methylene reduction also occurs. A mechanistic rationale for the fragmentation is advanced.

  克莱门森还原一系列 3-乙酰基环烷酮的主要产物是一种无环不饱和酮，即碎裂产物。一些正常的羰基-亚甲基还原反应也会发生。提出了破碎的机理依据。
• Electroorganic Chemistry. XXXIV. Novel Intramolecular Cyclization through Anodic Oxidation of Enol Acetates
  作者：Tatsuya Shono、Ikuzo Nishiguchi、Shigenori Kashimura、Masahisa Okawa

  DOI：10.1246/bcsj.51.2181

  日期：1978.7

  The anodic oxidation of 1-acetoxy-1,6-heptadiene homologues in acetic acid gave mainly intramolecular cyclization products, cyclohexenyl ketones. The cyclization takes place through the electrophilic attack of the cationic center generated from the enol ester moiety to the double bond.

  乙酸中 1-乙酰氧基-1,6-庚二烯同系物的阳极氧化主要产生分子内环化产物，环己烯基酮。环化通过从烯醇酯部分到双键产生的阳离子中心的亲电攻击而发生。
• Polar group-containing olefin copolymer, process for preparing the same, thermoplastic resin composition contaning the copolymer, and uses thereof
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP1186619A2

  公开（公告）日：2002-03-13

  The present invention is intended to provide a polar group-containing olefin copolymer having excellent adhesion properties to metals or polar resins and excellent compatibility therewith, a process for preparing the copolymer, a thermoplastic resin composition containing the copolymer, and uses thereof. The polar group-containing olefin copolymer comprises a constituent unit derived from an α-olefin of 2 to 20 carbon atoms, and a constituent unit derived from a straight-chain, branched or cyclic polar group-containing monomer having at the end a polar group such as a hydroxyl group or an epoxy group and/or a constituent unit derived from a macromonomer having at the end a polymer segment obtained by anionic polymerization, ring-opening polymerization or polycondensation. The polar group-containing olefin copolymer can be prepared by polymerizing the α-olefin with the polar group-containing monomer and/or the macromonomer in the presence of a metallocene catalyst. The polar group-containing olefin copolymer and the thermoplastic resin composition containing the copolymer are used for films, sheets, modifiers, building/civil engineering materials, automobile exterior trim, electric/electronic parts, coating bases, compatibilizing agents, etc.

  本发明旨在提供一种对金属或极性树脂具有极佳粘附性和相容性的含极性基团的烯烃共聚物、制备该共聚物的工艺、含有该共聚物的热塑性树脂组合物及其用途。含极性基团的烯烃共聚物包括一个由 2 至 20 个碳原子的 α-烯烃衍生的组成单元和一个由直链、支链或环状含极性基团单体衍生的组成单元，直链、支链或环状含极性基团单体的末端具有极性基团，如羟基或环氧基，和/或一个由大单体衍生的组成单元，大单体的末端具有通过阴离子聚合、开环聚合或缩聚反应获得的聚合物段。含极性基团的烯烃共聚物可通过在茂金属催化剂存在下使α-烯烃与含极性基团的单体和/或大单体聚合来制备。含极性基团的烯烃共聚物和含有该共聚物的热塑性树脂组合物可用于薄膜、板材、改性剂、建筑/土木工程材料、汽车外饰、电气/电子零件、涂层基料、相容剂等。
• Polar group-containing olefin copolymer, process for preparing the same, thermoplastic resin composition containing the copolymer, and uses thereof
  申请人：——

  公开号：US20020156207A1

  公开（公告）日：2002-10-24

  The present invention is intended to provide a polar group-containing olefin copolymer having excellent adhesion properties to metals or polar resins and excellent compatibility therewith, a process for preparing the copolymer, a thermoplastic resin composition containing the copolymer, and uses thereof. The polar group-containing olefin copolymer comprises a constituent unit derived from an &agr;-olefin of 2 to 20 carbon atoms, and a constituent unit derived from a straight-chain, branched or cyclic polar group-containing monomer having at the end a polar group such as a hydroxyl group or an epoxy group and/or a constituent unit derived from a macromonomer having at the end a polymer segment obtained by anionic polymerization, ring-opening polymerization or polycondensation. The polar group-containing olefin copolymer can be prepared by polymerizing the &agr;-olefin with the polar group-containing monomer and/or the macromonomer in the presence of a metallocene catalyst. The polar group-containing olefin copolymer and the thermoplastic resin composition containing the copolymer are used for films, sheets, modifiers, building/civil engineering materials, automobile exterior trim, electric/electronic parts, coating bases, compatibilizing agents, etc.

  本发明旨在提供一种对金属或极性树脂具有极佳粘附性能和极佳相容性的含极性基团的烯烃共聚物、制备该共聚物的工艺、含有该共聚物的热塑性树脂组合物及其用途。含极性基团的烯烃共聚物包括一个由 2 至 20 个碳原子的&agr;-烯烃衍生的组成单元，以及一个由直链、支链或环状含极性基团单体衍生的组成单元，该单体末端具有极性基团，如羟基或环氧基，和/或一个由大单体衍生的组成单元，该大单体末端具有通过阴离子聚合、开环聚合或缩聚反应获得的聚合物段。含极性基团的烯烃共聚物可通过在茂金属催化剂存在下，将&agr;-烯烃与含极性基团的单体和/或大单体进行聚合来制备。含极性基团的烯烃共聚物和含有该共聚物的热塑性树脂组合物可用于薄膜、板材、改性剂、建筑/土木工程材料、汽车外饰、电气/电子零件、涂层基料、相容剂等。