methyl 2-(4-chlorophenyl)-5-methyl-1-phenyl-1H-imidazole-4-carboxylate | 1572039-09-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 2-(4-chlorophenyl)-5-methyl-1-phenyl-1H-imidazole-4-carboxylate
• 英文别名: Methyl 2-(4-chlorophenyl)-5-methyl-1-phenylimidazole-4-carboxylate；methyl 2-(4-chlorophenyl)-5-methyl-1-phenylimidazole-4-carboxylate
• CAS: 1572039-09-8
• 化学式: C₁₈H₁₅ClN₂O₂
• 分子量: 326.782
• InChiKey: ZHUMRPWCNOVKIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲基3-苯胺基-2-丁烯酸酯 、 对氯苄胺 在 叔丁基过氧化氢 、 碘 、 copper(II) acetate monohydrate 、 碳酸氢钠 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 12.0h， 以78%的产率得到methyl 2-(4-chlorophenyl)-5-methyl-1-phenyl-1H-imidazole-4-carboxylate
  参考文献：
  名称：

  A concise synthesis of highly substituted imidazoles via copper-mediated oxidative C–H functionalization

  摘要：

  We herein report a simple and concise route for the synthesis of highly substituted imidazole derivatives via copper-mediated oxidative C-H functionalization in good to high yields. The advantage of the reaction lies in its mild reaction conditions and readily available starting materials. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.136

文献信息

• Electrochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles from enamines and benzylamines
  作者：Wenxing Wang、Shuo Zhang、Guang Shi、Zhiwei Chen

  DOI：10.1039/d1ob00942g

  日期：——

  An electrochemical method for synthesizing 1,2,4,5-tetrasubstituted imidazoles was developed under undivided electrolytic conditions. This synthesis was specifically realized based on electrochemical C(sp3)–H amination via enamines and amines. Readily available starting materials were used, avoiding the use of both transition metals and oxidants. The practicability of the method lies in its broad substrate

  在不分电解条件下开发了一种合成1,2,4,5-四取代咪唑的电化学方法。该合成是基于通过烯胺和胺的电化学 C(sp 3 )-H 胺化具体实现的。使用容易获得的起始材料，避免使用过渡金属和氧化剂。该方法的实用性在于其广泛的底物适应性和为合成GABA A受体类似物提供简单的绿色途径的能力。
• A concise synthesis of highly substituted imidazoles via copper-mediated oxidative C–H functionalization
  作者：Amit N. Pandya、Devendra K. Agrawal

  DOI：10.1016/j.tetlet.2014.01.136

  日期：2014.3

  We herein report a simple and concise route for the synthesis of highly substituted imidazole derivatives via copper-mediated oxidative C-H functionalization in good to high yields. The advantage of the reaction lies in its mild reaction conditions and readily available starting materials. (C) 2014 Elsevier Ltd. All rights reserved.