1-amino-2-methyl-4-phenylimidazole | 39678-35-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-amino-2-methyl-4-phenylimidazole
• 英文别名: 2-methyl-4-phenyl-imidazol-1-ylamine；1-Amino-2-methyl-4-phenylimidazol；2-Methyl-4-phenyl-1H-imidazol-1-amine；2-methyl-4-phenylimidazol-1-amine
• CAS: 39678-35-8
• 化学式: C₁₀H₁₁N₃
• 分子量: 173.217
• InChiKey: UNBLJRVBRKVLKM-UHFFFAOYSA-N

物化性质

• 沸点：
  392.1±35.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-amino-2-methyl-4-phenylimidazole 在 溶剂黄146 作用下， 以 乙二醇二甲醚 、 乙醇 为溶剂， 反应 10.0h， 生成 (E,E)-N-<3-dimethylamino-1-phenyl-2-propenylidene>-1H-2-methyl-4-phenyl-1,3-imidazol-1-amine
  参考文献：
  名称：

  A Novel Approach to the Synthesis of 1-Substituted-3,6-diaryl-imidazo[1,5-b]pyridazines

  摘要：

  A simple and efficient procedure for the preparation a new type of 1-substituted-3,6-diaryl-imidazo[ 1,5-b]pyridazines was described. This synthesis was carried out by the following three steps: Aryl methyl ketone 3 was condensed with 1-amino-2-substituted-4-arylimidazole 2 in ethanol with catalytic glacial acetic acid to afford enamines 4 a-k. Treatment with t-butoxybis(dimethylamino)methane in DME at room temperature gave enamine (5a-k) which was cyclized to compound (1a-k) in 84-96% yield in trifluoroacetic acid.

  DOI：

  10.1080/00397919508015480
• 作为产物：
  描述：

  1-(2,6-dichlorobenzylidenamino)-2-methyl-4-phenylimidazole 在 一水合肼 作用下， 以 乙二醇甲醚 为溶剂， 反应 13.0h， 生成 1-amino-2-methyl-4-phenylimidazole
  参考文献：
  名称：

  Cocco; Congiu; Plumitallo, Farmaco, Edizione Scientifica, 1987, vol. 42, # 5, p. 347 - 357

  摘要：

  DOI：

文献信息

• Antimicrobial imidazolium derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US04831151A1

  公开（公告）日：1989-05-16

  Compounds of the formula ##STR1## wherein the various substituents are defined hereinbelow and the pharmaceutically acceptable acid addition salts thereof, possess pharmacological properties. In particular, they possess antibacterial, antimycotic, protozoacidal and/or anthelmintic properties.

  公式为##STR1##的化合物，其中各种取代基在下文中定义，并且其药用酸盐是可以接受的，具有药理学特性。特别是，它们具有抗菌，抗真菌，原虫杀灭和/或驱虫特性。
• 1,3-Disubstituierte Imidazoliumsalze
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0200947B1

  公开（公告）日：1990-09-12
• US4831151A
  申请人：——

  公开号：US4831151A

  公开（公告）日：1989-05-16
• A Novel Approach to the Synthesis of 1-Substituted-3,6-diaryl-imidazo[1,5-b]pyridazines
  作者：Xumiao Zhao、Ruqiang Zhang

  DOI：10.1080/00397919508015480

  日期：1995.10

  A simple and efficient procedure for the preparation a new type of 1-substituted-3,6-diaryl-imidazo[ 1,5-b]pyridazines was described. This synthesis was carried out by the following three steps: Aryl methyl ketone 3 was condensed with 1-amino-2-substituted-4-arylimidazole 2 in ethanol with catalytic glacial acetic acid to afford enamines 4 a-k. Treatment with t-butoxybis(dimethylamino)methane in DME at room temperature gave enamine (5a-k) which was cyclized to compound (1a-k) in 84-96% yield in trifluoroacetic acid.
• Cocco; Congiu; Plumitallo, Farmaco, Edizione Scientifica, 1987, vol. 42, # 5, p. 347 - 357
  作者：Cocco、Congiu、Plumitallo、Schivo、Palmieri

  DOI：——

  日期：——