摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

6-methoxy-7-chloro-4-hydroxy-2-methoxycarbonylquinoline | 20843-50-9

中文名称
——
中文别名
——
英文名称
6-methoxy-7-chloro-4-hydroxy-2-methoxycarbonylquinoline
英文别名
methyl 7-chloro-6-methoxy-4-oxo-1H-quinoline-2-carboxylate
6-methoxy-7-chloro-4-hydroxy-2-methoxycarbonylquinoline化学式
CAS
20843-50-9
化学式
C12H10ClNO4
mdl
——
分子量
267.669
InChiKey
MPAAKJHSTVGSHE-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.2
  • 重原子数:
    18
  • 可旋转键数:
    3
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.17
  • 拓扑面积:
    64.6
  • 氢给体数:
    1
  • 氢受体数:
    5

反应信息

  • 作为反应物:
    参考文献:
    名称:
    Quinoline-Carboxylic acids are potent inhibitors that inhibit the binding of insulin-Like growth factor (IGF) to IGF-Binding proteins
    摘要:
    4-Benzylquinolines 5, based on a series of isoquinolines 1, were prepared and tested as inhibitors of the IGF/IGFBP-3 complex based on their ability to displace IGF-I from its binding to IGF-binding protein-3. SAR studies on the 6,7-dihydroxy moiety of the quinoline 5a showed that the catecol moiety could be replaced with other functional groups. Computational modeling of the 5a/mini-IGFBP-5 complex revealed the possible binding site of 5a on IGFBP-5. (C) 2003 Elsevier Science Ltd. All rights reserved.
    DOI:
    10.1016/s0960-894x(03)00322-6
  • 作为产物:
    参考文献:
    名称:
    Quinoline-Carboxylic acids are potent inhibitors that inhibit the binding of insulin-Like growth factor (IGF) to IGF-Binding proteins
    摘要:
    4-Benzylquinolines 5, based on a series of isoquinolines 1, were prepared and tested as inhibitors of the IGF/IGFBP-3 complex based on their ability to displace IGF-I from its binding to IGF-binding protein-3. SAR studies on the 6,7-dihydroxy moiety of the quinoline 5a showed that the catecol moiety could be replaced with other functional groups. Computational modeling of the 5a/mini-IGFBP-5 complex revealed the possible binding site of 5a on IGFBP-5. (C) 2003 Elsevier Science Ltd. All rights reserved.
    DOI:
    10.1016/s0960-894x(03)00322-6
点击查看最新优质反应信息

文献信息

  • Platelet adenosine diphosphate receptor antagonists
    申请人:Schering Aktiengesellschaft
    公开号:US20030060474A1
    公开(公告)日:2003-03-27
    Compounds of the following formula (I): 1 where a, b, R 1 , R 2 , R 4 and R 6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
    以下公式(I)的化合物:其中a、b、R1、R2、R4和R6如下所述,可用作抑制血小板腺苷二磷酸的药物。本文还描述了含有这些化合物的药物组合物,使用这些化合物作为抗血栓药物的方法以及合成这些化合物的过程。
  • PIPERAZINE OXYQUINOLINE (NAPHTHALINE) PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS
    申请人:Schering Aktiengesellschaft
    公开号:EP1412349A2
    公开(公告)日:2004-04-28
  • 2-AMINOCARBONYL-QUINOLINE COMPOUNDS AS PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS
    申请人:Bayer Schering Pharma Aktiengesellschaft
    公开号:EP1578423B1
    公开(公告)日:2010-08-18
  • US6861424B2
    申请人:——
    公开号:US6861424B2
    公开(公告)日:2005-03-01
  • US6995156B2
    申请人:——
    公开号:US6995156B2
    公开(公告)日:2006-02-07
查看更多