2-苯氧基乙硫醇 | 6338-63-2

• 物质功能分类: 化学试剂 - 有机试剂 - 硫醇盐
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-苯氧基乙硫醇
• 英文名称: 2-Phenoxy-aethylmercaptan
• 英文别名: 2-Phenoxy-ethylmercaptan；2-phenoxyethanethiol；2-Phenoxy-aethanthiol；(2-Mercapto-aethyl)-phenyl-aether
• CAS: 6338-63-2
• 化学式: C₈H₁₀OS
• mdl: MFCD03427071
• 分子量: 154.233
• InChiKey: WGZWXVFLOUVQLH-UHFFFAOYSA-N

物化性质

• 沸点：
  201-202 °C(lit.)
• 密度：
  1.105 g/mL at 25 °C(lit.)
• 闪点：
  >230 °F
• 稳定性/保质期：
  在常温常压下稳定，避免与强氧化剂接触。

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  10.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• WGK Germany：
  3
• 海关编码：
  2930909090
• 储存条件：
  密闭保存于阴凉干燥处，并且容器内已充入氮气。

反应信息

• 作为反应物：
  描述：

  2-苯氧基乙硫醇 在 lithium hydroxide 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.5h， 生成 <1α,2α(Z),3α,4α>-(+/-)-7-<3-<<(2-Phenoxyethyl)thio>methyl>-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoic acid
  参考文献：
  名称：

  9,11-Epoxy-9-homo-14-thiaprost-5-enoic acid derivatives: potent thromboxane A2 antagonists

  摘要：

  A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor. Compound (-)-10 was the only stereoisomer out of eight possible structures that was active. Thioether (-)-10 was 30-40-fold more potent than another TxA2 antagonist, BM 13.177, in inhibiting arachidonic acid (AA) induced aggregation of human platelet-rich plasma. Compound (-)-10 was effective (I50 = 0.5 +/- 0.4 microM) in inhibiting 9,11-azo-PGH2-induced (0.1 microgram/mL) contraction of guinea pig tracheal spirals. The bronchoconstriction in anesthetized guinea pigs induced by AA was also effectively antagonized by (-)-10 (1 mg/kg, iv); however, in this assay (-)-10 exhibited some direct agonist activity. Radioligand binding studies in washed (human) platelets revealed that (-)-10 is one of the most potent ligands for the PGH2/TxA2 receptor yet described (Kd = 1.6 +/- 0.4 nM).

  DOI：

  10.1021/jm00125a009
• 作为产物：
  描述：

  己二酸,聚合2,2-二甲基-1,3-丙二醇和2,5-呋喃二酮,苯酸酯 在 lithium aluminium tetrahydride 、 硫酸 、 氢溴酸 作用下， 生成 2-苯氧基乙硫醇
  参考文献：
  名称：

  Mass spectrometry in structural and stereochemical problems. CLV. Electron impact induced fragmentations and rearrangements of some trimethylsilyl ethers of aliphatic glycols, and related compounds

  摘要：

  DOI：

  10.1021/jo01270a022

文献信息

• Compositions for oxidatively dyeing keratin fibers and methods for using such compositions
  申请人：Lim Mu'Ill

  公开号：US20070209123A1

  公开（公告）日：2007-09-13

  Compositions for dyeing keratin fibers comprise (a) at least one keratin dyeing compound selected from aromatic systems which comprise at least one boronic acid or boronic ester moiety and which are capable of forming upon oxidation a nucleophile or an electrophile, (b) at least one additional keratin dyeing compound selected from the group consisting of auxiliary developers and auxiliary couplers, and (c) a cosmetically suitable medium. Methods for oxidatively dyeing keratin fibers comprise the steps of applying such compositions in the presence of an oxidizing agent and rinsing the hair. A hair coloring product in kit form comprises a first separately packaged container comprising a composition as described above and a second separately packaged container comprising an oxidizing agent.

  用于染色的组合物包括：(a)至少一种选自含有至少一个硼酸或硼酸酯基团的芳香族系统的角蛋白染料化合物，这些化合物在氧化时能够形成亲核物或亲电子物；(b)至少一种额外的角蛋白染料化合物，选自辅助显色剂和辅助偶联剂的组合；(c)一种化妆品适用的介质。氧化染角蛋白纤维的方法包括在氧化剂存在下应用这样的组合物，并冲洗头发。一种套装形式的头发染色产品包括一个第一独立包装容器，其中包含上述描述的组合物，以及一个第二独立包装容器，其中包含氧化剂。
• Macrolides with antibacterial activity
  申请人：——

  公开号：US20030199459A1

  公开（公告）日：2003-10-23

  The invention provides new macrolides antibiotics of formula (I) with improved biological properties and improved stability formula (I): wherein R 1 is hydrogen, cyano, —S(L) m R 2 , —S(O)(L) m R 2 , or —S(O) 2 (L) m R 2 ; L represents —(CH 2 ) n — or —(CH 2 ) n Z(CH 2 ) n′ —-; m is 0 or 1; n is 1, 2, 3, or 4; n′ is 0, 1, 2, 3, or 4; Z is O, S or NH; R2 is hydrogen, alkyl, heterocyclyl or aryl; which heterocyclyl and the aryl groups may be further substituted; * indicates a chiral center which is in the (R) or (S) form and pharmaceutically acceptable acid addition salts or in vivo cleavable esters thereof. 1

  该发明提供了具有改进生物性能和改进稳定性的新大环内酯类抗生素的公式(I)：其中R1为氢、氰基、—S(L)mR2、—S(O)(L)mR2或—S(O)2(L)mR2；L代表—(CH2)n—或—(CH2)nZ(CH2)n′—；m为0或1；n为1、2、3或4；n′为0、1、2、3或4；Z为O、S或NH；R2为氢、烷基、杂环烷基或芳基；其中杂环烷基和芳基基团可能进一步取代；*表示手性中心，为(R)或(S)形式，以及其药学上可接受的酸盐或体内可水解酯。
• [EN] 5- (SUBSTITUTED PHENYL) -THIADIAZOLIDINE-3-ONES AND THEIR USE AS PTP1B<br/>[FR] THIADIAZOLIDINE-3-ONES 5-(PHENYLE SUBSTITUE) ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PTP1B
  申请人：ASTRAZENECA AB

  公开号：WO2004041799A1

  公开（公告）日：2004-05-21

  The invention concerns compounds of the formula (I) or pharmaceutically acceptable salts thereof (A chemical formula should be inserted here - please see paper copy enclosed herewith) wherein R1, R2, R3, R4, R5, and R6 have any of the meanings defined in the description. Processes for the manufacture of compounds of formula (I), compositions containing them, their use as inhibitors of protein tyrosine phosphatase PTP1B and their use for the treatment of diabetes mellitus are also described.

  本发明涉及公式(I)的化合物或其药用可接受的盐（请参见随附的纸质副本中的化学公式）其中，R1、R2、R3、R4、R5和R6具有说明书中定义的任何含义。还描述了制造公式(I)化合物的方法、包含它们的组合物、它们作为蛋白酪氨酸磷酸酶PTP1B的抑制剂的使用以及它们用于治疗糖尿病的方法。
• Ring opening reactions of thiiranes by alkoxo- and aryloxo-gold(I) complexes
  作者：Yoko Usui、Junko Noma、Masafumi Hirano、Sanshiro Komiya

  DOI：10.1039/a907574g

  日期：——

  Alkoxo- and aryloxo-gold(I) complexes [Au(OR)L] [R = CH(CF3)2, L = PPh3 1a or PCy3 1b; R = Ph, L = PPh3 1c, PCy3 1d or PMe3 1e] smoothly reacted with ethylene sulfide to give the corresponding 2-(alkoxy- or -aryloxy)ethylsulfanylgold(I) complexes [Au(SCH2CH2OR)L] 2 at room temperature. Similar treatments of 1a–1e with propylene sulfide, isobutylene sulfide, or styrene sulfide selectively cleaved the

  烷氧基-和芳氧基-金（I）配合物[Au（OR）L] [R = CH（CF 3）2，L = PPh 3 1a或PCy 3 1b; R = Ph，L = PPh 3 1c，PCy 3 1d或PMe 3 1e]与硫化亚乙基平滑反应，生成相应的2-（烷氧基-或-芳氧基）乙基磺酰金（I）配合物[Au（SCH 2 CH 2 OR） L] 2在室温下。用硫化丙烯，异丁烯硫化物或苯乙烯硫化物对1a-1e进行类似处理，可选择性地裂解噻吩的较少受阻的C-S键，得到相应的2-（烷氧基-或-芳氧基）乙基磺基硫醇（I）复合体。与1a的反应顺式-和反式-2-丁烯，得到硫化物顺式和反分别[AU（SCHMeCHMeOR）L]，这表明涉及一个S的机构Ñ 2型反式加成alkoxogold（的我）朝向硫杂丙环的络合物。
• Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
  申请人：Lim Mu'lll

  公开号：US20060156481A1

  公开（公告）日：2006-07-20

  Compositions for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and at least one N-oxides of six-membered rings with one or two nitrogen atoms keratin dyeing compound. A method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration.

  氧化染色角蛋白纤维的配方，包括适用于染色的介质和至少一种含有一个或两个氮原子的六元环N-氧化物的角蛋白染料化合物。一种氧化染色角蛋白纤维的方法，包括在氧化剂存在下施用这种配方，以足够时间发展所需的着色。