2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate | 167298-18-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate
• 英文别名: [(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-[2-chloro-6-(2,2-diphenylethylamino)purin-9-yl]oxolan-2-yl]methyl benzoate
• CAS: 167298-18-2
• 化学式: C₄₅H₃₆ClN₅O₇
• 分子量: 794.263
• InChiKey: DJVOGLJHFQHVJZ-LSZAAVILSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  58
• 可旋转键数：
  16
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  144
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate 在 氢氧化钾 、 potassium permanganate 、 氯化亚砜 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 甲醇 、 丙酮 为溶剂， 生成 (3aS,4S,6R,6aR)-6-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carbonyl chloride
  参考文献：
  名称：

  The discovery and synthesis of highly potent, A 2a receptor agonists

  摘要：

  A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A(2a) and A(1) receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A(2a) receptor on the human neutrophil. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00017-2
• 作为产物：
  描述：

  1-乙酰基-三-苄氧基-罗伯糖 在 N,N-二异丙基乙胺 作用下， 以 异丙醇 为溶剂， 生成 2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate
  参考文献：
  名称：

  The discovery and synthesis of highly potent, A 2a receptor agonists

  摘要：

  A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A(2a) and A(1) receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A(2a) receptor on the human neutrophil. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00017-2

文献信息

• 2-6-diaminopurine precursors
  申请人：Glaxo Group Limited

  公开号：US05889178A1

  公开（公告）日：1999-03-30

  The present invention relates to compounds of formula (IV): ##STR1## wherein R.sup.a and R.sup.b each represent a hydrogen atom or together form an alkylidene group.

  本发明涉及化合物的公式(IV)：##STR1##其中R.sup.a和R.sup.b分别代表氢原子或共同形成一个烷基亚烯基团。
• 2,6-Di (substitutedamino) purine ribonucleoside analogues and
  申请人：Glaxo Group Limited

  公开号：US05925624A1

  公开（公告）日：1999-07-20

  The present invention relates to 2,6-diaminopurine-.beta.-D-ribofuranuronamide derivatives of the following formula (I). These compounds and their salts and solvates are useful as anti-inflammatory agents, particularly in the treatment of patients with inflammatory conditions who are susceptible to leukocyte-induced tissue damage. ##STR1##

  本发明涉及以下式(I)的2,6-二氨基嘌呤-.beta.-D-核糖醛酰脲衍生物。这些化合物及其盐和溶剂化物可用作抗炎剂，特别是用于治疗易受白细胞引起的组织损伤的炎症病患者。
• 2,6-DIAMINOPURINE DERIVATIVES
  申请人：GLAXO GROUP LIMITED

  公开号：EP0680488B1

  公开（公告）日：1998-04-08
• US5889178A
  申请人：——

  公开号：US5889178A

  公开（公告）日：1999-03-30
• US5925624A
  申请人：——

  公开号：US5925624A

  公开（公告）日：1999-07-20