(R)-4-[(R)-(tert-Butyl-dimethyl-silanyloxy)-(5-trimethylsilanyl-furan-3-yl)-methyl]-2,2-dimethyl-[1,3]dioxolane | 194476-08-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-4-[(R)-(tert-Butyl-dimethyl-silanyloxy)-(5-trimethylsilanyl-furan-3-yl)-methyl]-2,2-dimethyl-[1,3]dioxolane
• 英文别名: tert-butyl-[(R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-(5-trimethylsilylfuran-3-yl)methoxy]-dimethylsilane
• CAS: 194476-08-9
• 化学式: C₁₉H₃₆O₄Si₂
• 分子量: 384.663
• InChiKey: ZKTBRMSTAYFYFY-NVXWUHKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.04
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  40.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-4-[(R)-(tert-Butyl-dimethyl-silanyloxy)-(5-trimethylsilanyl-furan-3-yl)-methyl]-2,2-dimethyl-[1,3]dioxolane 在 过氧乙酸 、 sodium acetate 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 以70%的产率得到3-[(R)-[tert-butyl(dimethyl)silyl]oxy-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl]-2H-furan-5-one
  参考文献：
  名称：

  Total Syntheses of Sphydrofuran, Secosyrins, and Syributins^,1

  摘要：

  Two groups of natural products, sphydrofuran (1) and its furan derivative (2) and secosyrins 1 and 2 (3a, 3b) and syributins 1 and 2 (4a, 4b), were synthesized from one precursor (6), which was realized starting from 3-tri-n-butylstannylfuran or 3-bromofuran.

  DOI：

  10.1021/jo970476+
• 作为产物：
  描述：

  ((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-furan-3-yl-methanone 在 4-二甲氨基吡啶 、 正丁基锂 、 三乙基硼氢化锂 、 三乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 11.0h， 生成 (R)-4-[(R)-(tert-Butyl-dimethyl-silanyloxy)-(5-trimethylsilanyl-furan-3-yl)-methyl]-2,2-dimethyl-[1,3]dioxolane
  参考文献：
  名称：

  Total Syntheses of Sphydrofuran, Secosyrins, and Syributins^,1

  摘要：

  Two groups of natural products, sphydrofuran (1) and its furan derivative (2) and secosyrins 1 and 2 (3a, 3b) and syributins 1 and 2 (4a, 4b), were synthesized from one precursor (6), which was realized starting from 3-tri-n-butylstannylfuran or 3-bromofuran.

  DOI：

  10.1021/jo970476+

文献信息

• Total Syntheses of Sphydrofuran, Secosyrins, and Syributins^,¹
  作者：Pei Yu、Yun Yang、Ze Ying Zhang、Thomas C. W. Mak、Henry N. C. Wong

  DOI：10.1021/jo970476+

  日期：1997.9.1

  Two groups of natural products, sphydrofuran (1) and its furan derivative (2) and secosyrins 1 and 2 (3a, 3b) and syributins 1 and 2 (4a, 4b), were synthesized from one precursor (6), which was realized starting from 3-tri-n-butylstannylfuran or 3-bromofuran.