N-(4-acetylphenyl)-3,4-dimethoxybenzenesulfonamide | 693815-24-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(4-acetylphenyl)-3,4-dimethoxybenzenesulfonamide
• CAS: 693815-24-6
• 化学式: C₁₆H₁₇NO₅S
• 分子量: 335.381
• InChiKey: AQBDADNDEWUFTG-UHFFFAOYSA-N

物化性质

• 沸点：
  507.9±60.0 °C(Predicted)
• 密度：
  1.299±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(4-acetylphenyl)-3,4-dimethoxybenzenesulfonamide 在 氢溴酸 、 pyrrolidone hydrotribromide 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  α-Mercaptoketone based histone deacetylase inhibitors

  摘要：

  In an effort to discover novel non-hydroxamic acid histone deacetylase (HDAC) inhibitors, a novel alpha-mercaptoketone was identified in a high-throughput screen. Lead optimization of the screening hit, led to a number of potent HDAC inhibitors. In particular, alpha-mercaptoketone 19y (KD5150) exhibited nanomolar in vitro activity and inhibition of tumor growth in vivo. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.058
• 作为产物：
  描述：

  3,4-二甲氧基苯磺酰氯 、 4-氨基苯乙酮 在 吡啶 作用下， 反应 1.0h， 生成 N-(4-acetylphenyl)-3,4-dimethoxybenzenesulfonamide
  参考文献：
  名称：

  α-Mercaptoketone based histone deacetylase inhibitors

  摘要：

  In an effort to discover novel non-hydroxamic acid histone deacetylase (HDAC) inhibitors, a novel alpha-mercaptoketone was identified in a high-throughput screen. Lead optimization of the screening hit, led to a number of potent HDAC inhibitors. In particular, alpha-mercaptoketone 19y (KD5150) exhibited nanomolar in vitro activity and inhibition of tumor growth in vivo. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.058

文献信息

• Single-Electron-Transfer-Generated Aryl Sulfonyl Ammonium Salt: Metal-Free Photoredox-Catalyzed Modular Construction of Sulfonamides
  作者：Fengying Yan、Qing Li、Shanshan Fu、Yuxing Yang、Duoqi Yang、Shun Yao、Man Song、Hong Deng、Xianwei Sui

  DOI：10.1021/acscatal.4c00816

  日期：2024.4.5

  construction of aryl sulfonamides via an aryl sulfonyl ammonium salt intermediate, which was generated in situ via a SET event, has been established. A variety of structurally diverse primary, secondary, and tertiary aryl sulfonamides were synthesized rapidly from abundant amines or sodium azide under mild conditions. Notably, the primary aliphatic amine, which remains challenging in the Cu-catalyzed protocols

  磺胺类化合物在有机合成和药物化学中具有突出的作用。然而，用于芳基磺酰胺模块化结构的通用合成平台仍然难以捉摸。在此，通过芳基磺酰铵盐中间体建立了无金属光氧化还原催化的芳基磺酰胺三组分结构，该中间体通过SET 事件原位生成。在温和条件下，由丰富的胺或叠氮化钠快速合成了多种结构多样的伯、仲和叔芳基磺酰胺。值得注意的是，脂肪族伯胺在铜催化方案中仍然具有挑战性，但在这种方法中效果良好。此外，以氟化氢钾为亲核试剂，也可以顺利合成芳基磺酰氟。这种转换的潜在效用在三种生物活性药物化合物的简便构建中得到了证明。初步的机理研究表明，芳基磺酰基自由基和芳基磺酰铵盐是这种机械创新方法中的关键中间体。
• α-Mercaptoketone based histone deacetylase inhibitors
  作者：Paul L. Wash、Timothy Z. Hoffman、Brandon M. Wiley、Céline Bonnefous、Nicholas D. Smith、Michael S. Sertic、Charles M. Lawrence、Kent T. Symons、Phan-Manh Nguyen、Kevin D. Lustig、Xin Guo、Tami Annable、Stewart A. Noble、Jeffrey H. Hager、Christian A. Hassig、James W. Malecha

  DOI：10.1016/j.bmcl.2008.10.058

  日期：2008.12

  In an effort to discover novel non-hydroxamic acid histone deacetylase (HDAC) inhibitors, a novel alpha-mercaptoketone was identified in a high-throughput screen. Lead optimization of the screening hit, led to a number of potent HDAC inhibitors. In particular, alpha-mercaptoketone 19y (KD5150) exhibited nanomolar in vitro activity and inhibition of tumor growth in vivo. (C) 2008 Elsevier Ltd. All rights reserved.