3,4,8-三甲氧基-1-甲基喹啉-2-酮 | 90475-68-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3,4,8-三甲氧基-1-甲基喹啉-2-酮
• 英文名称: Swietenidin-A methyl ether
• 英文别名: Swietenidin-A-monomethylether；3,4,8-Trimethoxy-1-methylquinolin-2(1H)-one；3,4,8-trimethoxy-1-methylquinolin-2-one
• CAS: 90475-68-6
• 化学式: C₁₃H₁₅NO₄
• 分子量: 249.266
• InChiKey: MTKCKSBCXFDXHU-UHFFFAOYSA-N

物化性质

• 沸点：
  414.4±45.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-methoxymalonanilic acid ethyl ester 在 盐酸 、 氢氧化钾 、 sodium hydroxide 、 双氧水 、 溶剂黄146 、 锌 作用下， 以 甲醇 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.59h， 生成 3,4,8-三甲氧基-1-甲基喹啉-2-酮
  参考文献：
  名称：

  Bhide, K. S.; Mujumdar, R. B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1983, vol. 22, # 12, p. 1254 - 1256

  摘要：

  DOI：

文献信息

• Quinolinone derivative, method for preparing the same, and anti-allergic agent
  申请人：Dainippon Ink and Chemicals, Inc.

  公开号：US06271416B1

  公开（公告）日：2001-08-07

  The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method, novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following general formula (I), is reacted with a basic agent, followed by intramolecular ring formation: General Formula (I) [wherein, R1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group, an alkenyl group, or an aryl group; R2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R3 represents a reactive carboxyl group; and R4 to R7 represent, respectively and independently, a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxy group, an alkenyl group, an alkenyloxy group, an aryl group, an aryloxy group, an aralkyloxy group, a R8R9N group (wherein, R8 and R9 represent, respectively and independently, a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl group, or an acyl group), a nitro group, or a R10OOC group (wherein, R10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group)]. General Formula (II) [wherein, R1, R2 and R4 to R7 represent, respectively, the same constituents as described in general formula (I)].

  本发明涉及一种简单的制备喹诺酮衍生物的方法，该方法可作为药物，例如用作治疗过敏性疾病等的药剂；在该方法中作为中间体的新型酰胺衍生物，根据该方法获得的新型喹诺酮衍生物；以及含有喹诺酮衍生物和/或其生理盐作为活性成分的抗过敏剂。喹诺酮衍生物由以下通式（II）表示；该方法的特点在于，将由以下通式（I）表示的酰胺衍生物与碱性试剂反应，然后进行分子内环形成：通式（I）中，R1表示氢原子、烷基、含有羟基的烷基、烯基或芳基；R2表示烷基、烯基、芳基或芳基烷基；R3表示反应性羧基；R4至R7分别且独立地表示氢原子、羟基、烷基、烷氧基、烯基、烯氧基、芳基、芳氧基、芳基烷氧基、R8R9N基（其中，R8和R9分别且独立地表示氢原子、烷基、烯基、芳基烷基或酰基）、硝基或R10OOC基（其中，R10表示氢原子、烷基、烯基、芳基或芳基烷基）；通式（II）中，R1、R2和R4至R7分别表示与通式（I）中描述的相同成分。
• Quinolinone derivative, method for preparing the same, and anti-allergic
  申请人：Dainippon Ink and Chemicals, Inc.

  公开号：US06136822A1

  公开（公告）日：2000-10-24

  The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method; novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following formula (I), is reacted with a basic agent, followed by intramolecular ring formation: ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group an alkenyl group, or an aryl group; R.sub.2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R.sub.3 represents a reactive carboxyl group; and R.sub.4 to R.sub.7 represent, respectively and independently, a hydrogen atom; a hydroxyl group; an alkyl group; an alkoxy group; an alkenyl group; an alkenyloxy group; an aryl group; an aryloxy group; an aralkyloxy group; a R.sub.8 R.sub.9 N group wherein R.sub.8 and R.sub.9 represent, respectively and independently, a hydrogen atom, an alkyl group, an alkenyl group an aralkyl group, or an acyl group; a nitro group; or a R.sub.10 OOC group wherein R.sub.10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; ##STR2## wherein R.sub.1, R.sub.2 and R.sub.4 to R.sub.7 represent, respectively, the same constituents as described in formula (I).

  本发明涉及一种简单的制备喹啉酮衍生物的方法，该衍生物可作为药物，例如作为治疗过敏性疾病等的药剂；在该方法中作为中间体的新型酰胺衍生物；根据该方法获得的新型喹啉酮衍生物；以及含有喹啉酮衍生物和/或其生理盐作为活性成分的抗过敏剂。喹啉酮衍生物由以下通式（II）表示；而该方法的特点在于将以下式（I）表示的酰胺衍生物与碱性试剂反应，随后发生分子内环形成：##STR1## 其中，R1代表氢原子，烷基，含有羟基的烷基，烯基或芳基；R2代表烷基，烯基，芳基或芳基烷基；R3代表反应性羧基；R4到R7分别且独立地代表氢原子；羟基；烷基；烷氧基；烯基；烯氧基；芳基；芳氧基；芳基烷氧基；R8R9N基，其中R8和R9分别且独立地代表氢原子，烷基，烯基，芳基烷基或酰基；硝基；或R10OOC基，其中R10代表氢原子，烷基，烯基，芳基或芳基烷基；##STR2## 其中，R1，R2和R4到R7分别表示与式（I）中所述相同的成分。
• Quinolinone derivative and antiallergic agent with said quinolinone derivative as the active ingredient
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0785190A2

  公开（公告）日：1997-07-23

  The present invention offers 7-aminoquinolinone derivatives, physiologically acceptable salts thereof, anti-allergic agents having as an active ingredient a 7-aminoquinolinone derivative or physiologically acceptable salt thereof, and 7-nitroquinolinone derivatives, wherein the 7-aminoquinolinone derivative is expressed by the following general formula (I):    wherein R1 is a hydrogen atom or an alkyl group; R2 and R3 are mutually different groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups or alkenyl groups; and R4 and R5 are mutually different or identical groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups, alkenyl groups or aralkyl groups; and physiologically acceptable salts thereof.

  本发明提供了7-氨基喹啉酮衍生物、其生理学上可接受的盐、以7-氨基喹啉酮衍生物或其生理学上可接受的盐为活性成分的抗过敏剂，以及7-硝基喹啉酮衍生物，其中7-氨基喹啉酮衍生物由以下通式(I)表示： 其中 R1 是氢原子或烷基； R2 和 R3 是互不相同的基团，每个基团选自氢原子、酰基、烷基或烯基；以及 R4 和 R5 是相互不同或相同的基团，各自选自氢原子、酰基、烷基、烯基或芳烷基； 及其生理上可接受的盐类。
• US5942521A
  申请人：——

  公开号：US5942521A

  公开（公告）日：1999-08-24
• US6114352A
  申请人：——

  公开号：US6114352A

  公开（公告）日：2000-09-05