N'-(4-chloro-5,6,7,8-tetrahydroquinolin-3-yl)-N,N-dimethylmethanimidamide | 151225-15-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N'-(4-chloro-5,6,7,8-tetrahydroquinolin-3-yl)-N,N-dimethylmethanimidamide
• CAS: 151225-15-9
• 化学式: C₁₂H₁₆ClN₃
• 分子量: 237.732
• InChiKey: UESBXUKPVGCDHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N'-(4-chloro-5,6,7,8-tetrahydroquinolin-3-yl)-N,N-dimethylmethanimidamide 在 硫酸 作用下， 反应 1.5h， 以96%的产率得到3-amino-4-chloro-5,6,7,8-tetrahydroquinoline
  参考文献：
  名称：

  Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines

  摘要：

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(96)02071-0
• 作为产物：
  描述：

  1-吗啉基-1-环己烯 在 三氯氧磷 作用下， 以 二氯甲烷 、 乙酸酐 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 N'-(4-chloro-5,6,7,8-tetrahydroquinolin-3-yl)-N,N-dimethylmethanimidamide
  参考文献：
  名称：

  Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines

  摘要：

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(96)02071-0

文献信息

• Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines
  作者：Makoto Adachi、Takashi Sasatani、Nobuo Chomei、Susumu Takada

  DOI：10.1016/s0040-4039(96)02071-0

  日期：1996.12

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.