2-(2-Acetylphenyl)-3-methyl-1H-inden-1-one | 185628-55-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-Acetylphenyl)-3-methyl-1H-inden-1-one
• 英文别名: 2-(2-acetylphenyl)-3-methylinden-1-one
• CAS: 185628-55-1
• 化学式: C₁₈H₁₄O₂
• 分子量: 262.308
• InChiKey: ZKODFONHNFUUFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  双(2-乙炔基苯基)乙炔 在 PtCl₄-CO 水 作用下， 以 四氢呋喃 为溶剂， 80.0 ℃ 、137.89 kPa 条件下， 反应 5.5h， 以91%的产率得到2-(2-Acetylphenyl)-3-methyl-1H-inden-1-one
  参考文献：
  名称：

  Hydration of Alkynes by a PtCl₄−CO Catalyst

  摘要：

  Treatment of PtCl4 with CO at 40-110 degrees C forms a powerful alkyne hydration catalyst that operates both under homogeneous conditions in wet THF and under phase-transfer conditions in (CHCl2)(2)/H2O in the presence of tricaprylmethylammonium chloride (Aliquat 336). Complex HPtCl(CO)(2) is regarded as the active hydration catalyst. It is assumed to be formed by initial transformation of PtCl4 to H-2[Pt-3(CO)(6)](n), (n = 5, 6) followed by reaction with HCl (generated by decomposition of the starting platinum salt).

  DOI：

  10.1021/jo961740m

文献信息

• Isoquinoline derivatives and methods of use thereof
  申请人：Inotek Pharmaceuticals Corporation

  公开号：EP2033645A1

  公开（公告）日：2009-03-11

  The present invention relates to Isoquinoline Derivatives, compositions comprising an effective amount of a Isoquinoline Derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease other than a cardiovascular disease, cardiovascular disease, reoxygenation injury resulting from organ transplantation, Parkinson's disease, or cancer, comprising administering to an animal in need thereof an effective amount of a Isoquinoline Derivative.

  本发明涉及异喹啉衍生物、包含有效量异喹啉衍生物的组合物以及用于治疗或预防炎症性疾病、再灌注损伤、缺血性疾病、肾衰竭、糖尿病、糖尿病并发症、心血管疾病以外的血管疾病、心血管疾病、器官移植导致的再氧损伤、帕金森病或癌症的方法，包括向有需要的动物施用有效量的异喹啉衍生物。
• SUBSTITUTED INDENO [1,2-C]ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF
  申请人：Inotek Pharmaceuticals Corporation

  公开号：EP1420785B1

  公开（公告）日：2010-04-28
• Hydration of Alkynes by a PtCl₄−CO Catalyst
  作者：Waël Baidossi、Michal Lahav、Jochanan Blum

  DOI：10.1021/jo961740m

  日期：1997.2.1

  Treatment of PtCl4 with CO at 40-110 degrees C forms a powerful alkyne hydration catalyst that operates both under homogeneous conditions in wet THF and under phase-transfer conditions in (CHCl2)(2)/H2O in the presence of tricaprylmethylammonium chloride (Aliquat 336). Complex HPtCl(CO)(2) is regarded as the active hydration catalyst. It is assumed to be formed by initial transformation of PtCl4 to H-2[Pt-3(CO)(6)](n), (n = 5, 6) followed by reaction with HCl (generated by decomposition of the starting platinum salt).