2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile | 101544-43-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile
• 英文别名: 5-[1-hydroxy-2-(dibenzylamino)ethyl]-7-cyanoindoline；2,3-dihydro-5-[1-hydroxy-2-(bis(phenylmethyl)amino)ethyl]-1H-indole-7-carbonitrile；5-[2-(dibenzylamino)-1-hydroxyethyl]-2,3-dihydro-1H-indole-7-carbonitrile
• CAS: 101544-43-8
• 化学式: C₂₅H₂₅N₃O
• 分子量: 383.493
• InChiKey: LZFWTTIZGJQTSI-UHFFFAOYSA-N

物化性质

• 沸点：
  579.5±50.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  59.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile 在 双氧水 作用下， 以 二甲基亚砜 为溶剂， 反应 0.25h， 生成 2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide
  参考文献：
  名称：

  Indole-phenol-bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analog of labetalol

  摘要：

  The synthesis of 5-[hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-1H-indole-7- carboxamide, 5, a pyrrolo analogue of labetalol, is described. Compound 5 was found to reduce blood pressure in spontaneously hypertensive rats with an ED50 of 5 mg/kg po, without causing any decrease in heart rate. Isolated tissue studies with 5 shows that it is a nonselective beta-adrenoceptor antagonist and that it is a weaker alpha-adrenoceptor antagonist with a relative selectivity for alpha 1-receptors. Additionally, the compound displayed significant beta-adrenoceptor intrinsic sympathomimetic activity. Evidence is presented that the beta-adrenoceptor antagonist and agonist properties of 5 are mediated via hydrogen-bond formation with the receptor.

  DOI：

  10.1021/jm00156a019
• 作为产物：
  描述：

  1-乙酰基-5-(氯乙酰基)二氢吲哚 在 吡啶 、 盐酸 、 potassium cyanide 、 sodium hydroxide 、 sodium tetrahydroborate 、 tetrafluoroboric acid 、 硝酸 、 溶剂黄146 、 锌 、 sodium nitrite 作用下， 以 乙醇 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.33h， 生成 2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile
  参考文献：
  名称：

  Indole-phenol-bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analog of labetalol

  摘要：

  The synthesis of 5-[hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-1H-indole-7- carboxamide, 5, a pyrrolo analogue of labetalol, is described. Compound 5 was found to reduce blood pressure in spontaneously hypertensive rats with an ED50 of 5 mg/kg po, without causing any decrease in heart rate. Isolated tissue studies with 5 shows that it is a nonselective beta-adrenoceptor antagonist and that it is a weaker alpha-adrenoceptor antagonist with a relative selectivity for alpha 1-receptors. Additionally, the compound displayed significant beta-adrenoceptor intrinsic sympathomimetic activity. Evidence is presented that the beta-adrenoceptor antagonist and agonist properties of 5 are mediated via hydrogen-bond formation with the receptor.

  DOI：

  10.1021/jm00156a019

文献信息

• 5-Indolyl substituted aminoethanols
  申请人：American Home Products Corp.

  公开号：US04521606A1

  公开（公告）日：1985-06-04

  Herein is disclosed bicyclic-substituted aminoethanol derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for treating hypertension in a mammal.

  本文披露了双环取代氨基乙醇衍生物，其治疗可接受的酸盐，其制备过程，衍生物的使用方法和制药组合物。这些衍生物可用于治疗哺乳动物的高血压。
• ASSELIN A. A.; HUMBER L. G.; CROSILLA D.; OSHIRO G.; WOJDAN A.; GRIMES D.+, J. MED. CHEM., 29,(1986) N 6, 1009-1015
  作者：ASSELIN A. A.、 HUMBER L. G.、 CROSILLA D.、 OSHIRO G.、 WOJDAN A.、 GRIMES D.+

  DOI：——

  日期：——
• ——
  作者：ASSELIN A. A.、 CROSILLA D. A.、 HUMBER L. G.

  DOI：——

  日期：——
• US4521606A
  申请人：——

  公开号：US4521606A

  公开（公告）日：1985-06-04
• US4562200A
  申请人：——

  公开号：US4562200A

  公开（公告）日：1985-12-31