5,6,8-trimethylquinoline | 116529-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,6,8-trimethylquinoline
• 英文别名: 5,6,8-trimethyl-quinoline；5,6,8-Trimethyl-chinolin
• CAS: 116529-89-6
• 化学式: C₁₂H₁₃N
• 分子量: 171.242
• InChiKey: HUTKYWOITCJFIC-UHFFFAOYSA-N

物化性质

• 沸点：
  285.999±0.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.034±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5,6,8-trimethylquinoline 在 三氟乙酸 作用下， 反应 5.0h， 生成 5,6,8-trimethyl-7-[(1E)-prop-1-en-1-yl]quinoline
  参考文献：
  名称：

  METHODS OF DESIGNING, PREPARING, AND USING NOVEL PROTONOPHORES

  摘要：

  本发明提供了一种利用计算机辅助的方法来生成需要使用处理器的质子载体。该方法包括：设计质子载体，使用处理器计算估计的质子载体活性；如果估计的质子载体活性对应于大约20微米或更少的U50，则生产质子载体；并确定质子载体的解耦活性。本发明还提供了符合上述要求的新型质子载体及其使用方法。

  公开号：

  US20140135359A1
• 作为产物：
  描述：

  2,4,5-三甲基苯胺 、 甘油 在 硫酸 、 硝基苯 作用下， 生成 5,6,8-trimethylquinoline
  参考文献：
  名称：

  Wikander, Chemische Berichte, 1900, vol. 33, p. 648

  摘要：

  DOI：

文献信息

• REACTIVE COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150353583A1

  公开（公告）日：2015-12-10

  A reactive compound represented by the following formula (I): [In the formula (I), Z represents a divalent group. A plurality of Y may be the same or different, and represent a monovalent boronate residue having at least one hydroxyl group, Ar 1 and Ar 2 may be the same or different, and represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group.].

  由以下公式（I）表示的一种反应性化合物： [在公式（I）中，Z代表二价基团。多个Y可以相同也可以不同，并表示至少有一个羟基的一价硼酸酯残基，Ar1和Ar2可以相同也可以不同，并表示三价芳香烃基团或三价杂环基团。]。
• BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20140296246A1

  公开（公告）日：2014-10-02

  This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R 1a , R 1b , R 2a , R 2b , R 3 , and X are described herein.

  本申请涉及一种化合物，它可以作为溴域含有蛋白质（包括溴域含有蛋白质4（BRD4））的抑制剂或调节剂，以及包含这种化合物的组合物和配方，以及使用和制备这种化合物的方法。该化合物包括公式（I）中所描述的R1a，R1b，R2a，R2b，R3和X的化合物。
• Berend, Chemische Berichte, 1885, vol. 18, p. 376
  作者：Berend

  DOI：——

  日期：——
• Polymer complex compound and polymer light emitting device using the same
  申请人：Mikami Satoshi

  公开号：US20070040164A1

  公开（公告）日：2007-02-22

  A polymer complex compound comprising a repeating unit of the following formula (1) and a metal complex structure showing light emission from triplet excited state, having visible light emission in the solid state, and having a polystyrene reduced number-average molecular weight of 10 3 to 10 8 : (wherein, Ring P and Ring Q each independently represent an aromatic ring, but Ring P may be either existent or non-existent. When Ring P is existent, two connecting bonds respectively are on Ring P and/or Ring Q, and when Ring P is non-existent, two connecting bonds respectively are on 5 membered ring containing Y, and/or Ring Q. Y represents —O—, —S— and the like).
• Polymer light-emitting material and polymer light-emitting device
  申请人：Nakatani Tomoya

  公开号：US20070051922A1

  公开（公告）日：2007-03-08

  A polymer light emitting material which contains a polymer compound comprising a repeating unit of the following formula (1) or (2) and having a polystyrene-reduced number-average molecular weight of 10 3 to 10 8 , and which exhibits light emission from the triplet excited state. [wherein Ar 1 and Ar 2 each independently represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group. X 1 and X 2 each independently represent O, S, C(═O), S(═O), SO 2 , C(R 1 )(R 2 ), Si(R 3 )(R 4 ), N(R 5 ), B(R 6 ), P(R 7 ) or P(═O)(R 8 ). X 1 and Ar 2 bond to adjacent carbon atoms in the aromatic ring of Ar 1 ; and X 2 and Ar 1 bond to adjacent carbon atoms in the aromatic ring of Ar 2 ]; [wherein Ar 3 and Ar 4 each independently represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group. X 3 and X 4 each independently represent N, B, P, C(R 9 ) or Si(R 10 ). X 3 and Ar 4 bond to adjacent carbon atoms in the aromatic ring of Ar 3 ; and X 4 and Ar 3 bond to adjacent carbon atoms in the aromatic ring of Ar 4 ].