1-[4-(4-Fluorophenyl)thiophen-2-yl]ethanone | 748817-88-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-(4-Fluorophenyl)thiophen-2-yl]ethanone
• CAS: 748817-88-1
• 化学式: C₁₂H₉FOS
• 分子量: 220.267
• InChiKey: GECRANQNXFYHNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[4-(4-Fluorophenyl)thiophen-2-yl]ethanone 在 一水合肼 作用下， 以 二乙二醇 为溶剂， 以27%的产率得到2-ethyl-4-(p-fluorophenyl)thiophene
  参考文献：
  名称：

  Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus

  摘要：

  A new series of analogues of 4-(4-fluorophenyl)-2-methylthio-thiophene-3-carbonitrile (1) were synthesized and evaluated for their in vitro and in vivo anthelmintic activity against Haemonchus contortus. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.044
• 作为产物：
  描述：

  4-溴-2-乙酰基噻吩 、 4-氟苯硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 以97%的产率得到1-[4-(4-Fluorophenyl)thiophen-2-yl]ethanone
  参考文献：
  名称：

  Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus

  摘要：

  A new series of analogues of 4-(4-fluorophenyl)-2-methylthio-thiophene-3-carbonitrile (1) were synthesized and evaluated for their in vitro and in vivo anthelmintic activity against Haemonchus contortus. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.044

文献信息

• Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus
  作者：Isabel C González、Leon N Davis、Charles K Smith

  DOI：10.1016/j.bmcl.2004.05.044

  日期：2004.8

  A new series of analogues of 4-(4-fluorophenyl)-2-methylthio-thiophene-3-carbonitrile (1) were synthesized and evaluated for their in vitro and in vivo anthelmintic activity against Haemonchus contortus. (C) 2004 Elsevier Ltd. All rights reserved.