3,5-二氟-4-羟甲基苯甲酸 | 1211596-29-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-二氟-4-羟甲基苯甲酸
• 英文名称: 3,5-Difluoro-4-(hydroxymethyl)benzoic acid
• CAS: 1211596-29-0
• 化学式: C₈H₆F₂O₃
• 分子量: 188.13
• InChiKey: KJXISPQWLQRHDO-UHFFFAOYSA-N

物化性质

• 沸点：
  329.3±42.0 °C(Predicted)
• 密度：
  1.514±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• PLANT DISEASE CONTROL AGENT, AND PLANT DISEASE CONTROL METHOD
  申请人：Komori Takashi

  公开号：US20100137445A1

  公开（公告）日：2010-06-03

  Disclosed is a plant disease control agent comprising an amide compound represented by the formula (1) as an active ingredient. wherein X 1 represents a fluorine atom or a methoxy group; X 2 represents a hydrogen atom, a halogen atom, a C 1 -C 4 alkyl group, a C 2 -C 4 alkenyl group, a C 1 -C 4 haloalkyl group, a C 1 -C 4 alkoxy group, a C 1 -C 4 alkylthio group, a C 1 -C 4 hydroxyalkyl group and so on; Z 1 represents an oxygen atom or a sulfur atom; A 1 represents a single bond, —CH 2 — and so on; and G 1 represents a group CR 6 R 7 R 8 , a C 3-6 cycloalkyl group and so on.

  本发明公开了一种植物病害控制剂，其包含以式（1）表示的酰胺化合物作为活性成分。其中，X1代表氟原子或甲氧基；X2代表氢原子、卤素原子、C1-C4烷基、C2-C4烯基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4烷硫基、C1-C4羟基烷基等；Z1代表氧原子或硫原子；A1代表单键、—CH2—等；G1代表CR6R7R8基团、C3-6环烷基等。
• Azabenzimidazole derivatives as agonists of the AMP-activated protein kinase
  申请人：Boehringer Ingelheim International GmbH

  公开号：US10307402B2

  公开（公告）日：2019-06-04

  The present invention relates to compounds of general formula I, wherein the group R1, X and Y are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

  本发明涉及通式 I 的化合物，其中基团 R1、X 和 Y 的定义如权利要求 1 所述，这些化合物具有重要的药理特性，特别是能与 AMP 活化蛋白激酶 (AMPK) 结合并调节其活性。这些化合物适用于治疗和预防可受该受体影响的疾病，如代谢性疾病，特别是 2 型糖尿病。
• NEW AZABENZIMIDAZOLE DERIVATIVES AS AGONISTS OF THE AMP-ACTIVATED PROTEIN KINASE
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP3245210A1

  公开（公告）日：2017-11-22
• New Azabenzimidazole Derivatives as Agonists of the AMP-Activated Protein Kinase
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20180028500A1

  公开（公告）日：2018-02-01

  The present invention relates to compounds of general formula I, wherein the group R 1 , X and Y are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
• [EN] NEW AZABENZIMIDAZOLE DERIVATIVES AS AGONISTS OF THE AMP-ACTIVATED PROTEIN KINASE<br/>[FR] NOUVEAUX DÉRIVÉS D'AZABENZIMIDAZOLE EN TANT QU'AGONISTES DE LA PROTÉINE KINASE ACTIVÉE PAR L'AMP
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2016113300A1

  公开（公告）日：2016-07-21

  The present invention relates to compounds of general formula I, wherein the group R1, X and Y are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.