1,2,3,4-tetrahydroquinoline-8-sulfonamide | 142598-01-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,2,3,4-tetrahydroquinoline-8-sulfonamide
• CAS: 142598-01-4
• 化学式: C₉H₁₂N₂O₂S
• 分子量: 212.272
• InChiKey: HYUCRLKRVXGLEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2,3,4-tetrahydroquinoline-8-sulfonamide 在 三氯氧磷 作用下， 以 甲苯 为溶剂， 反应 50.0h， 生成 2-chloro-4λ6-thia-1,3-diazatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene 4,4-dioxide
  参考文献：
  名称：

  Nagarajan, Kuppuswamy; Bhat, Ganapati A.; Rao, Vunnam Ranga, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1992, vol. 31, # 6, p. 310 - 315

  摘要：

  DOI：
• 作为产物：
  描述：

  喹啉-8-磺酰胺 在 platinum(IV) oxide 氢气 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 23.0h， 以90%的产率得到1,2,3,4-tetrahydroquinoline-8-sulfonamide
  参考文献：
  名称：

  Nagarajan, Kuppuswamy; Bhat, Ganapati A.; Rao, Vunnam Ranga, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1992, vol. 31, # 6, p. 310 - 315

  摘要：

  DOI：

文献信息

• Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
  申请人：AbbVie S.à.r.l.

  公开号：US20180244640A1

  公开（公告）日：2018-08-30

  The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

  本发明涉及化合物及其在囊性纤维化治疗中的应用，其生产方法，包含相同化合物的药物组合物，以及通过给予本发明化合物治疗囊性纤维化的方法。
• Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
  申请人：AbbVie S.à.r.l.

  公开号：US10428017B2

  公开（公告）日：2019-10-01

  The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

  本发明涉及治疗囊性纤维化的化合物及其用途、生产方法、包含本发明化合物的药物组合物，以及通过施用本发明化合物治疗囊性纤维化的方法。
• LIGANDS FOR ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS AND METHODS OF TREATING NEUROLOGICAL AND INFLAMMATORY CONDITIONS
  申请人：Northeastern University

  公开号：EP3180086A1

  公开（公告）日：2017-06-21
• Ligands for Alpha-7 Nicotinic Acetylcholine Receptors and Methods of Treating Neurological and Inflammatory Conditions
  申请人：Northeastern University

  公开号：US20170217984A1

  公开（公告）日：2017-08-03

  Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. The compounds also can be used to enhance memory and learning in normal individuals.
• [EN] LIGANDS FOR ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS AND METHODS OF TREATING NEUROLOGICAL AND INFLAMMATORY CONDITIONS<br/>[FR] LIGANDS POUR LA SOUS-UNITÉ ALPHA-7 DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE ET MÉTHODES DE TRAITEMENT DE TROUBLES NEUROLOGIQUES ET INFLAMMATOIRES
  申请人：UNIV NORTHEASTERN

  公开号：WO2016014847A1

  公开（公告）日：2016-01-28

  Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. The compounds also can be used to enhance memory and learning in normal individuals.