(1R,3R,4S)-3-benzoyl-2-<(1S)-phenylethyl>-2-azabicyclo<2.2.1>hept-5-ene | 223473-34-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1R,3R,4S)-3-benzoyl-2-<(1S)-phenylethyl>-2-azabicyclo<2.2.1>hept-5-ene
• 英文别名: (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]hept-5-ene-3-phenylketone；phenyl-[(1R,3R,4S)-2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-en-3-yl]methanone
• CAS: 223473-34-5
• 化学式: C₂₁H₂₁NO
• 分子量: 303.404
• InChiKey: KTGGJZOSUCZLML-JOCLIGHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1R,3R,4S)-3-benzoyl-2-<(1S)-phenylethyl>-2-azabicyclo<2.2.1>hept-5-ene 在 palladium dihydroxide 、 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 为溶剂， -78.0~20.0 ℃ 、2.03 MPa 条件下， 反应 52.5h， 生成 (1S,3R,4R)-2-Azabicyclo[2.2.1]heptane-3-(R)-phenylmethanol
  参考文献：
  名称：

  A Theoretical and Experimental Study of the Asymmetric Addition of Dialkylzinc toN-(Diphenylphosphinoyl)benzalimine

  摘要：

  The mechanism of the enantioselective addition of diethylzinc to N(diphenylphosphinoyl)benzalimine with catalysis by bicyclic 2-azanorbornyl-3-methanols was studied by quantum chemical calculations. The mechanism proved to differ from that of the addition of diethylzinc to aldehydes and also from an earlier proposed mechanism. The results of the calculations were used to identify several factors responsible for the selectivity. The theoretical evaluation was performed in connection with an experimental study of the effects of introducing an additional stereocenter in the ligand. An efficient route to both diastereomers of new bicyclic 2-azanorbornyl-3-methanols with an additional chiral center (the secondary alcohol group) is also presented. In the best case, an enantiomeric excess of up to 97% was obtained with these new ligands.

  DOI：

  10.1002/(sici)1521-3765(19990604)5:6<1692::aid-chem1692>3.0.co;2-m
• 作为产物：
  描述：

  环戊二烯 、 2-{1'-[(1'S)-1'-phenylethyl]imino}phenylethanone 在 三氟化硼乙醚 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 (1R,3R,4S)-3-benzoyl-2-<(1S)-phenylethyl>-2-azabicyclo<2.2.1>hept-5-ene
  参考文献：
  名称：

  A Theoretical and Experimental Study of the Asymmetric Addition of Dialkylzinc toN-(Diphenylphosphinoyl)benzalimine

  摘要：

  The mechanism of the enantioselective addition of diethylzinc to N(diphenylphosphinoyl)benzalimine with catalysis by bicyclic 2-azanorbornyl-3-methanols was studied by quantum chemical calculations. The mechanism proved to differ from that of the addition of diethylzinc to aldehydes and also from an earlier proposed mechanism. The results of the calculations were used to identify several factors responsible for the selectivity. The theoretical evaluation was performed in connection with an experimental study of the effects of introducing an additional stereocenter in the ligand. An efficient route to both diastereomers of new bicyclic 2-azanorbornyl-3-methanols with an additional chiral center (the secondary alcohol group) is also presented. In the best case, an enantiomeric excess of up to 97% was obtained with these new ligands.

  DOI：

  10.1002/(sici)1521-3765(19990604)5:6<1692::aid-chem1692>3.0.co;2-m

文献信息

• New Expedient Route to Both Enantiomers of Nonproteinogenic α-Amino Acid Derivatives from the Unsaturated 2-Aza-Bicyclo Moiety
  作者：Diego A. Alonso、Sophie K. Bertilsson、Sandra Y. Johnsson、Sofia J. M. Nordin、Mikael J. Södergren、Pher G. Andersson

  DOI：10.1021/jo981838w

  日期：1999.4.1

  The influence of the reaction conditions on the catalytic hydrogenation of 2-aza-bicyclo hept-5-ene and oct-5-ene derivatives has been investigated. We found it possible to fully control the extent of allylic vs benzylic C-N hydrogenolysis by simple variations of H-2 pressure and acidity of the reaction medium. The use of the reaction pathways was demonstrated by the selective preparation of four categories of optically active alpha-amino acid derivatives. The strategy was also extended to the synthesis of enantiopure alpha-amino ketones.