N²,N⁶-bis(phenoxyacetyl)-2,6-diamino-9-(β-D-2-deoxyribofuranosyl) purine | 156549-47-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N²,N⁶-bis(phenoxyacetyl)-2,6-diamino-9-(β-D-2-deoxyribofuranosyl) purine
• 英文别名: 2'-Deoxy-2-(2-phenoxyacetamido)-N-(phenoxyacetyl)adenosine；N-[9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-[(2-phenoxyacetyl)amino]purin-6-yl]-2-phenoxyacetamide
• CAS: 156549-47-2
• 化学式: C₂₆H₂₆N₆O₇
• 分子量: 534.528
• InChiKey: MABTYOCUBSWBGZ-NNMXDRDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  170
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N²,N⁶-bis(phenoxyacetyl)-2,6-diamino-9-(β-D-2-deoxyribofuranosyl) purine 在 4-二甲氨基吡啶 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 反应 20.0h， 生成 5'-O-dimethoxytrityl-N²,N⁶-bis(phenoxyacetyl)-2,6-diaminopurine-2'-deoxyriboside 3'-O-succinate
  参考文献：
  名称：

  Synthesis of Oligodeoxyribonucleotides Containing 2,6-Diaminopurine

  摘要：

  The preparation of a new protected derivative of 2,6-diaminopurine 2'-deoxyriboside carrying two phenoxyacetyl groups is described. The new derivative is useful to prepare oligonucleotides containing 2,6-diaminopurine and it is deprotected at the same time as the standard protecting groups of the natural bases.

  DOI：

  10.1080/15257779408013258
• 作为产物：
  描述：

  苯氧乙酰氯 在 ammonium hydroxide 、 三甲基氯硅烷 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 反应 16.5h， 生成 N²,N⁶-bis(phenoxyacetyl)-2,6-diamino-9-(β-D-2-deoxyribofuranosyl) purine
  参考文献：
  名称：

  Synthesis of Oligodeoxyribonucleotides Containing 2,6-Diaminopurine

  摘要：

  The preparation of a new protected derivative of 2,6-diaminopurine 2'-deoxyriboside carrying two phenoxyacetyl groups is described. The new derivative is useful to prepare oligonucleotides containing 2,6-diaminopurine and it is deprotected at the same time as the standard protecting groups of the natural bases.

  DOI：

  10.1080/15257779408013258

文献信息

• Synthesis of Oligodeoxyribonucleotides Containing 2,6-Diaminopurine
  作者：Angeles Canol、Myron F. Goodman、Ramon Eritja

  DOI：10.1080/15257779408013258

  日期：1994.3

  The preparation of a new protected derivative of 2,6-diaminopurine 2'-deoxyriboside carrying two phenoxyacetyl groups is described. The new derivative is useful to prepare oligonucleotides containing 2,6-diaminopurine and it is deprotected at the same time as the standard protecting groups of the natural bases.