5-epixanthoperol | 119817-27-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5-epixanthoperol
• 英文别名: xanthopel；12-hydroxyabieta-8,11,13-triene-6,7-dione；hypargenin C；11α-Xanthoperol；5,7-Epixanthoperol；(4aS,10aS)-6-hydroxy-1,1,4a-trimethyl-7-propan-2-yl-2,3,4,10a-tetrahydrophenanthrene-9,10-dione
• CAS: 119817-27-5
• 化学式: C₂₀H₂₆O₃
• 分子量: 314.425
• InChiKey: KVTOPOITUALWOF-AZUAARDMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• USE CERTAIN DITERPENE COMPOUNDS IN THE TREATMENT OF ANDROGEN RECEPTOR-ASSOCIATED DISEASES
  申请人：HSIAO Pei-Wen

  公开号：US20100022632A1

  公开（公告）日：2010-01-28

  The present invention discloses certain diterpenes that can be used to inhibit androgen receptor activity, induce apoptosis and block cell cycle progression of androgen receptor-dependent cells. Androgen receptor has been associated with various diseases such as prostate cancer, androgeneic alopecia, breast cancer, acne etc. Accordingly, the present invention further discloses methods of treating androgen receptor-associated diseases by administering the disclosed diterpenes.
• US8519007B2
  申请人：——

  公开号：US8519007B2

  公开（公告）日：2013-08-27