methyl (E)-3-(3-hydroxyphenyl)-2-methylacrylate | 1229231-35-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: methyl (E)-3-(3-hydroxyphenyl)-2-methylacrylate
• 英文别名: methyl (E)-3-(3-hydroxyphenyl)-2-methylprop-2-enoate
• CAS: 1229231-35-9
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: WLASGOHBMCKDAC-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Decan-4-yloxy-ethynyl-di(propan-2-yl)silane 在 氟化氢吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以26 mg的产率得到methyl (E)-3-(3-hydroxyphenyl)-2-methylacrylate
  参考文献：
  名称：

  Ethynyldiisopropylsilyl: A New Alkynylsilane Protecting Group and “Click” Linker

  摘要：

  A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports In a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-CI) as a functionalized protecting group linker.

  DOI：

  10.1021/ol100968t

文献信息

• A Robust First-Pass Protocol for the Heck–Mizoroki Reaction
  作者：Paul M. Murray、John F. Bower、David K. Cox、Ewan K. Galbraith、Jeremy S. Parker、Joseph B. Sweeney

  DOI：10.1021/op300364p

  日期：2013.3.15

  The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.
• Ethynyldiisopropylsilyl: A New Alkynylsilane Protecting Group and “Click” Linker
  作者：Pallavi Sharma、John E. Moses

  DOI：10.1021/ol100968t

  日期：2010.6.18

  A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports In a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-CI) as a functionalized protecting group linker.