4-(5-methoxy-8-formylnaphthalen-1-yloxy)naphthalene-1-carbaldehyde | 521285-13-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(5-methoxy-8-formylnaphthalen-1-yloxy)naphthalene-1-carbaldehyde
• 英文别名: 8-(4-Formylnaphthalen-1-yl)oxy-4-methoxynaphthalene-1-carbaldehyde
• CAS: 521285-13-2
• 化学式: C₂₃H₁₆O₄
• 分子量: 356.378
• InChiKey: YGGOAMSRFQIKJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(5-methoxy-8-formylnaphthalen-1-yloxy)naphthalene-1-carbaldehyde 在 间氯过氧苯甲酸 、 氢氧化钾 作用下， 以 二氯甲烷 、 四氢呋喃 、 甲醇 为溶剂， 反应 15.25h， 以64%的产率得到4-(5-methoxy-8-hydroxynaphthalen-1-yloxy)naphth-1-ol
  参考文献：
  名称：

  Synthesis of Highly Oxygenated Dinaphthyl Ethers via S_NAr Reactions Promoted by Barton's Base

  摘要：

  [GRAPHIC]Electron-rich dinaphthyl ethers were synthesized by SNAr reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.

  DOI：

  10.1021/ol034286z
• 作为产物：
  描述：

  5-hydroxy-1-methoxy-4-naphthalenecarboxaldehyde 、 4-氟-1-萘醛 在 2-叔丁基-1,1,3,3-四甲基胍 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以85%的产率得到4-(5-methoxy-8-formylnaphthalen-1-yloxy)naphthalene-1-carbaldehyde
  参考文献：
  名称：

  Synthesis of Highly Oxygenated Dinaphthyl Ethers via S_NAr Reactions Promoted by Barton's Base

  摘要：

  [GRAPHIC]Electron-rich dinaphthyl ethers were synthesized by SNAr reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.

  DOI：

  10.1021/ol034286z

文献信息

• Synthesis of Highly Oxygenated Dinaphthyl Ethers via S_NAr Reactions Promoted by Barton's Base
  作者：Peter Wipf、Stephen M. Lynch

  DOI：10.1021/ol034286z

  日期：2003.4.1

  [GRAPHIC]Electron-rich dinaphthyl ethers were synthesized by SNAr reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.