E-1-methoxy-4-hexene | 134777-60-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: E-1-methoxy-4-hexene
• 英文别名: (E)-6-methoxyhex-2-ene
• CAS: 134777-60-9
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: LNDGSLSBOSCHMP-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  乙醛酸甲酯 、 E-1-methoxy-4-hexene 在 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 生成 (E)-2-Hydroxy-7-methoxy-3-methyl-hept-4-enoic acid methyl ester 、 2-Hydroxy-6-methoxy-3-vinyl-hexanoic acid methyl ester
  参考文献：
  名称：

  Remote asymmetric induction based on carbonyl-ene reactions with bishomoallylic silyl ethers: dramatic changeover of regioselectivity by the remarkable siloxy effect

  摘要：

  A new approach to remote asymmetric induction is described for not only a 1,4- but also a 1,5-relationship, which is based on the carbonyl-ene reactions with chiral bishomoallylic silyl ethers. Silyl ethers, rather than alkyl ethers, exhibit beta-regiospecificity. Remarkably high levels of remote asymmetric induction can then be established with chiral bishomoallylic ethers to provide eventually a simple and efficient method for asymmetric induction.

  DOI：

  10.1021/jo00049a011
• 作为产物：
  描述：

  4-己烯-1-醇 、 碘甲烷 在 sodium hydride 作用下， 以 三甘醇二甲醚 为溶剂， 生成 E-1-methoxy-4-hexene
  参考文献：
  名称：

  含有末端甲氧基的无支链己烯基甲基醚的拉曼光谱

  摘要：

  摘要 报道并讨论了六种异构的己烯基甲基醚的拉曼光谱，其中烯基链不带支链并具有末端甲氧基。在双键的立体化学和 ν (CC) 伸缩振动的波数之间发现了明确定义且在分析上有用的相关性。从 ν (sp 2 CH) 伸缩带的数量和波数可以确认双键的立体化学及其在烷基链中的位置。此外，观察到己烯基链中双键的性质对几种变形和骨架模式产生影响。这些趋势允许将拉曼谱带分配给振动模式以进行细化或校正。

  DOI：

  10.1016/j.molstruc.2009.08.038

文献信息

• [EN] QUINOXALINE-CONTAINING COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS<br/>[FR] COMPOSÉS CONTENANT DE LA QUINOXALINE EN TANT QU'INHIBITEURS DU VIRUS DE L'HÉPATITE C
  申请人：ENANTA PHARM INC

  公开号：WO2009064975A1

  公开（公告）日：2009-05-22

  The present invention discloses compounds of formula I and II or pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了抑制丝氨酸蛋白酶活性的I和II公式化合物，或其药物可接受的盐、酯或前药，尤其是抑制丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，并且也用作抗病毒剂。本发明进一步涉及包含前述化合物的药物组合物，用于给患有HCV感染的主体进行管理。本发明还涉及通过管理包含本发明化合物的药物组合物来治疗主体中的HCV感染的方法。
• METHOD FOR MANUFACTURING KETONE
  申请人：Kaneda Kiyotomi

  公开号：US20120197036A1

  公开（公告）日：2012-08-02

  A method for manufacturing a ketone, includes oxidizing an internal olefin or a cyclic olefin having a functional group containing a hetero atom and one carbon-carbon double bond or more at a position other than terminals of a molecule thereof in an amide-based solvent in the presence of water, a palladium catalyst, and molecular oxygen, without oxidizing the functional group, thereby bonding an oxo group to at least one of the carbon atoms constituting the carbon-carbon double bond. The amide-based solvent is represented by formula (1): wherein R 1 represents an alkyl group having 1 to 4 carbon atoms; R 2 and R 3 each independently represent an alkyl group having 1 to 4 carbon atoms or an aryl group; and when R 1 and R 2 are alkyl groups, R 1 and R 2 may be bonded to each other to form a ring structure.

  一种制备酮的方法，包括在酰胺基溶剂中，在水、钯催化剂和分子氧的存在下氧化具有异原子和一个或多个碳碳双键的内部烯烃或环烯烃，其功能团位于分子的端部以外的位置，而不氧化功能团，从而将氧代基键合到构成碳碳双键的至少一个碳原子上。酰胺基溶剂由式（1）表示：其中R1代表具有1至4个碳原子的烷基基团；R2和R3各自独立地代表具有1至4个碳原子的烷基基团或芳基；当R1和R2为烷基基团时，R1和R2可以结合在一起形成环结构。
• ORGANIC SULFUR COMPOUND AND ITS USE FOR CONTROLLING HARMFUL ARTHROPOD
  申请人：Miyazaki Hiroyuki

  公开号：US20100160434A1

  公开（公告）日：2010-06-24

  There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods represented by the formula (I): wherein, R 1 represents a C3-C10 alkenyl group optionally substituted with at least one halogen atom, a C3-C10 alkynyl group optionally substituted with at least one halogen atom, or the like, R 2 represents a cyano group or the like, R 3 represents a hydrogen atom, a halogen atom or a C1-C4 alkyl group, R 4 represents a C1-C5 fluoroalkyl group, and n represents 0, 1 or 2.

  提供了一种有机硫化合物，其对由式（I）所代表的有害节肢动物具有优异的控制效果：其中，R1代表C3-C10烯基，可选地取代至少一个卤素原子，C3-C10炔基，可选地取代至少一个卤素原子或类似基团；R2代表氰基或类似基团；R3代表氢原子、卤素原子或C1-C4烷基；R4代表C1-C5氟烷基；n代表0、1或2。
• THERAPEUTIC COMPOUNDS
  申请人：McCauley John A.

  公开号：US20110002884A1

  公开（公告）日：2011-01-06

  A class of macrocyclic compounds of formula (I), wherein R 1 , R 3 , R 4 , R a , R b , A, B, Z, M, W and n are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.

  提供一类具有化学式（I）的大环化合物，其中R1、R3、R4、Ra、Rb、A、B、Z、M、W和n在此定义，这些化合物可用作病毒蛋白酶抑制剂，特别是乙型肝炎病毒（HCV）NS3蛋白酶的抑制剂。还提供了合成和使用这种大环化合物用于治疗或预防HCV感染的过程。
• METHOD FOR PRODUCING EPOXY COMPOUND CONTAINING HYDROGEN PEROXIDE STABILIZER
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20170275258A1

  公开（公告）日：2017-09-28

  The present invention provides a method for producing an epoxy compound by a reaction of an olefin compound with hydrogen peroxide, wherein the epoxy compound is stably and safely produced using a hydrogen peroxide stabilizer for reducing an oxygen gas generated from hydrogen peroxide. A method for producing an epoxy compound by a reaction of an olefin compound with hydrogen peroxide, wherein the reaction is carried out in the presence of an organophosphorus compound in such a reaction medium that the pH is maintained within a range of more than 7.5 and less than 12.0. The olefin compound may be 1,3,5-tris-(alkenyl)-isocyanurate. The alkenyl group in the olefin compound may be 3-butenyl group, 4-pentenyl group, 5-hexenyl group, 6-heptenyl group, or 7-octenyl group. The epoxy compound may be 1,3,5-tris-(epoxyalkyl)-isocyanurate. The reaction medium may be such a reaction medium that the pH is maintained within a range of 8.0 to 10.5.

  本发明提供了一种通过烯烃化合物与过氧化氢反应制备环氧化合物的方法，其中使用过氧化氢稳定剂来减少从过氧化氢产生的氧气，从而稳定且安全地生产环氧化合物。该方法是在存在有机磷化合物的反应介质中进行反应，该反应介质的pH值保持在7.5以上且小于12.0的范围内。烯烃化合物可以是1,3,5-三（烯基）-异氰酸酯。烯基化合物中的烯基可以是3-丁烯基，4-戊烯基，5-己烯基，6-庚烯基或7-辛烯基。环氧化合物可以是1,3,5-三（环氧烷基）-异氰酸酯。反应介质可以是pH值保持在8.0至10.5的反应介质。