(1-benzyl-2-butyl-1H-cyclopenta[a]naphthalen-4-yl)hydrazine | 1229024-72-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (1-benzyl-2-butyl-1H-cyclopenta[a]naphthalen-4-yl)hydrazine
• 英文别名: 1-benzyl-2-butyl-4-hydrazinyl-1H-imidazo[4,5-c]quinoline；1-Benzyl-2-butyl-4-hydrazinyl-1Himidazo[4,5-c]quinoline；(1-benzyl-2-butylimidazo[4,5-c]quinolin-4-yl)hydrazine
• CAS: 1229024-72-9
• 化学式: C₂₁H₂₃N₅
• 分子量: 345.447
• InChiKey: ZLLPJLVKKQZGCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  68.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-叠氮基戊酸 、 (1-benzyl-2-butyl-1H-cyclopenta[a]naphthalen-4-yl)hydrazine 在 N-甲基吗啉 、 2-氯-4,6-二甲氧基-1,3,5-三嗪 作用下， 以 乙酸乙酯 为溶剂， 反应 16.0h， 生成 5-azido-N'-(1-benzyl-2-butylimidazo[4,5-c]quinolin-4-yl)pentanehydrazide
  参考文献：
  名称：

  [EN] EXPRESSION VECTOR DELIVERY SYSTEM AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE
  [FR] SYSTÈME D'ADMINISTRATION DE VECTEURS D'EXPRESSION ET UTILISATION DE CE DERNIER POUR INDUIRE UNE RÉPONSE IMMUNITAIRE

  摘要：

  公开号：

  WO2017044803A8

文献信息

• Expression vector delivery system and use thereof for inducing an immune response
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：US10799580B2

  公开（公告）日：2020-10-13

  Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.

  本发明提供了一种新型系统的实施方案，该系统可将编码抗原的表达载体递送至受试者体内，从而对刺激受试者对抗原的免疫反应进行时空控制。在一些实施方案中，表达载体递送系统包括与原药形式的佐剂相连的聚合物，该佐剂可形成聚合物纳米颗粒并在生理条件下进入细胞（如免疫细胞）。在某些实施方案中，佐剂通过酶可降解的易变键与聚合物连接，酶可降解的易变键的裂解可激活佐剂以刺激免疫反应。
• EXPRESSION VECTOR DELIVERY SYSTEM AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Servic

  公开号：US20210023208A1

  公开（公告）日：2021-01-28

  Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.
• [EN] EXPRESSION VECTOR DELIVERY SYSTEM AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE<br/>[FR] SYSTÈME D'ADMINISTRATION DE VECTEURS D'EXPRESSION ET UTILISATION DE CE DERNIER POUR INDUIRE UNE RÉPONSE IMMUNITAIRE
  申请人：US HEALTH

  公开号：WO2017044803A8

  公开（公告）日：2017-06-29