A new, general, and regioselective method for the 3-nitration of flavones have been developed. The nitration reaction is solvent dependent, proceeds via a nitro radical pathway, and the corresponding 3-nitroflavones have been obtained in moderate to very good yields (up to 81%). The reduction of 3-nitroflavones allowed the preparation of the corresponding 3-aminoflavones in very good yields (up to 96%).
我们开发了一种新的、通用的、具有区域选择性的
黄酮 3-硝化方法。硝化反应依赖于溶剂,通过硝基自由基途径进行,相应的
3-硝基
黄酮以中等到非常好的收率(高达 81%)获得。通过还原
3-硝基
黄酮,可以制备相应的 3-
氨基
黄酮,收率非常高(高达 96%)。