Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333
作者:Corinne Beinat、Tristan Reekie、David Hibbs、Teresa Xie、Thao T. Olson、Yingxian Xiao、Andrew Harvey、Susan O'Connor、Carolyn Coles、John Tsanaktsidis、Michael Kassiou
DOI:10.1016/j.ejmech.2014.07.029
日期:2014.9
further SAR exploration. The present work investigates the amide bond of SEN12333, specifically its connectivity and replacement with the tetrazole functionality, a known cis amide isostere. The results reveal the original amide bond connectivity of SEN12333 to be favorable for binding affinity and agonist activity at α7 nAChRs. The use of a tetrazole isostere completely abolishes affinity and functional
实验几条证据支持α参与7胆碱受体在精神分裂症和老年痴呆症。α7nAChR的调节剂已被广泛审查与这些病理相关的认知功能障碍的治疗。SEN12333代表一种新型的α7nAChR激动剂化学型,具有减少副作用的潜力,但需要进一步的SAR探索。本工作研究了SEN12333的酰胺键,特别是其连接性和被四唑官能团(一种已知的顺式)取代酰胺等排。结果表明,SEN12333的原始酰胺键连接性有利于在α7nAChRs上的结合亲和力和激动剂活性。使用四唑等排物完全消除了亲和力和功能活性,并表明SEN12333以线性构象结合。本文报道的结果还表明SEN12333的末端芳族环内的吡啶氮对于结合亲和力或功能活性不是必需的。有必要对涉及操纵SEN12333中包含的其他部分的SAR进行进一步的调查。