Epi-dihydrophaseic acid | 60102-38-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Epi-dihydrophaseic acid
• 英文别名: (2Z,4E)-5-[(1R,3R,5R,8S)-3,8-dihydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]-3-methylpenta-2,4-dienoic acid
• CAS: 60102-38-7
• 化学式: C₁₅H₂₂O₅
• 分子量: 282.33
• InChiKey: XIVFQYWMMJWUCD-FJBUYRLMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Modifiable chemical inducers of proximity and methods of using the same
  申请人：Clontech Laboratories, Inc.

  公开号：US10634668B2

  公开（公告）日：2020-04-28

  Methods of reversibly inducing proximity of first and second target molecules in a sample are provided. Aspects of the methods include contacting the sample with a modifiable chemical inducer of proximity (MCIP) that reversibly induces proximity of the first and second target molecules, upon application of a stimulus that modifies the MCIP. Aspects of the invention further include methods for regulating a biological process in a cell. Aspects of the invention further include compositions, e.g., compounds and kits, etc., that find use in methods of the invention.

  本文提供了可逆地诱导样品中第一和第二目标分子接近的方法。这些方法的各个方面包括将样品与可改变接近性的化学诱导剂（MCIP）接触，在施加可改变 MCIP 的刺激时，MCIP 可逆地诱导第一和第二目标分子接近。本发明的各个方面还包括调节细胞中生物过程的方法。本发明的各个方面还包括可用于本发明方法的组合物，例如化合物和试剂盒等。
• Alkenyl Substituted Cycloaliphatic Compounds as Chemical Inducers of Proximity
  申请人：Liang Fu-Sen

  公开号：US20130158098A1

  公开（公告）日：2013-06-20

  Methods of inducing proximity of chimeric molecules in a cell are provided. Aspects of the methods include contacting a cell with an amount of alkenyl substituted cycloaliphatic (ASC) inducer compound, e.g., abscisic acid, effective to induce proximity of first and second chimeric molecules. Also provided are compositions and kits for practicing various embodiments of the methods. Methods of the invention find use in a variety of different applications, including transcription induction applications.
• MODIFIABLE CHEMICAL INDUCERS OF PROXIMITY AND METHODS OF USING THE SAME
  申请人：Clontech Laboratories, Inc.

  公开号：US20140080137A1

  公开（公告）日：2014-03-20

  Methods of reversibly inducing proximity of first and second target molecules in a sample are provided. Aspects of the methods include contacting the sample with a modifiable chemical inducer of proximity (MCIP) that reversibly induces proximity of the first and second target molecules, upon application of a stimulus that modifies the MCIP. Aspects of the invention further include methods for regulating a biological process in a cell. Aspects of the invention further include compositions, e.g., compounds and kits, etc., that find use in methods of the invention.
• Modifiable Chemical Inducers of Proximity and Methods of Using the Same
  申请人：Takara Bio USA, Inc.

  公开号：US20200256858A1

  公开（公告）日：2020-08-13

  Methods of reversibly inducing proximity of first and second target molecules in a sample are provided. Aspects of the methods include contacting the sample with a modifiable chemical inducer of proximity (MCIP) that reversibly induces proximity of the first and second target molecules, upon application of a stimulus that modifies the MCIP. Aspects of the invention further include methods for regulating a biological process in a cell. Aspects of the invention further include compositions, e.g., compounds and kits, etc., that find use in methods of the invention.