trimethylsilyl 2-(4-bromophenoxy)ethyl ether | 113202-49-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: trimethylsilyl 2-(4-bromophenoxy)ethyl ether
• 英文别名: 4-(trimethylsiloxyethyloxy)bromobenzene；2-(4-Bromophenoxy)ethanol, TMS derivative；2-(4-bromophenoxy)ethoxy-trimethylsilane
• CAS: 113202-49-6
• 化学式: C₁₁H₁₇BrO₂Si
• 分子量: 289.244
• InChiKey: WKLCJSCSKVGOPH-UHFFFAOYSA-N

物化性质

• 沸点：
  293.0±20.0 °C(Predicted)
• 密度：
  1.216±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trimethylsilyl 2-(4-bromophenoxy)ethyl ether 在 咪唑 、 N-碘代丁二酰亚胺 、 四丁基氟化铵 、 溴 、 叔丁基锂 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 正戊烷 为溶剂， 反应 1.13h， 生成 1,2-diphenyl-2-iodo-1-[4-(2-methanesulfonyloxyethoxy)phenyl]ethylene
  参考文献：
  名称：

  [125I]Iododesethyl tamoxifen aziridine: Synthesis and covalent labeling of the estrogen receptor with an iodine-labeled affinity label

  摘要：

  Iododesethyl tamoxifen aziridine (I-Tam-Az), an analog of the estrogen receptor-affinity label tamoxifen aziridine (Tam-Az) in which the ethyl group has been replaced by an iodine, has been prepared by two routes: (a) metallation of a bromotriarylethylene system, followed by reaction with iodine, and aziridinylation, and (b) direct iodination of a trimethylstannyl triarylethylene system that is the immediate precursor of I-Tam-Az. The latter method can be used to prepare [125I]I-Tam-Az rapidly and in good yield, both at carrier-added and no-carrier-added levels; specific activities greater than 200 Ci/mmol have been obtained. In competitive radiometric binding assays with the estrogen receptor, I-Tam-Az has an apparent affinity of ca. 20%, equivalent to that of Tam-Az. It also undergoes rapid and selective time-dependent, irreversible binding to the estrogen receptor. [125I]I-Tam-Az reacts covalently with estrogen receptor in uterine cytosol preparations; its attachment is rapid and efficient, but somewhat less selective than that of Tam-Az. Estrogen receptor in intact MCF-7 human breast cancer cells can also be labeled with [125I]I-Tam-Az, and autoradiographic analysis of salt extracts of labeled nuclear estrogen receptor on SDS-polyacrylamide slab gels shows highly selective labeling of a 65K protein. [125I]I-Tam-Az is an efficient, selective affinity label for the estrogen receptor, available at high specific activity, and should be useful in studies on estrogen receptor structure, dynamics, and chromatin interactions.

  DOI：

  10.1016/0039-128x(86)90017-6
• 作为产物：
  描述：

  三甲基氯硅烷 、 2-(4-溴苯氧基)乙醇 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以19 g的产率得到trimethylsilyl 2-(4-bromophenoxy)ethyl ether
  参考文献：
  名称：

  광 염기 발생제

  摘要：

  本发明提供了一种含有比传统光敏碱发生剂对光更敏感的光敏碱发生剂和该光敏碱发生剂的感光性树脂组合物。 本发明是一种光敏碱发生剂，其具有含有一般式（1）所表示的盐的特征。 在一般式（1）中，R至R独立于彼此，表示如一般式（2）所示的基，该基是1至18个碳原子的烷基或芳基，但至少有一个基是表示为一般式（2）的基；在式（2）中，（D）表示至少有一个与硼元素结合的两个基，Ar与上述Ar相同；Q表示一个氧铵阳离子。

  公开号：

  KR20160048949A

文献信息

• 광 염기 발생제
  申请人：SAN-APRO LIMITED 산아프로 가부시키가이샤(520060478236)

  公开号：KR20160048949A

  公开（公告）日：2016-05-04

  종래의 광 염기 발생제보다 광에 대한 감도가 높은 광 염기 발생제 및 당해 염기 발생제를 함유하는 감광성 수지 조성물을 제공한다. 본 발명은, 일반식 (1) 로 나타내는 염을 함유하는 것을 특징으로 하는 광 염기 발생제이다. 〔식 (1) 중, R ∼ R는 서로 독립적으로, 하기 일반식 (2) 로 나타내는 기, 탄소수 1 ∼ 18 의 알킬기 또는 Ar 이지만, 단, 적어도 1 개가, 일반식 (2) 로 나타내는 기이며, ； 식 (2) 중, (D) 는 적어도 한쪽이 붕소 원소와 결합하는 2 가의 기이며, Ar 은 상기 Ar 과 동일하고 ； Q는 1 가의 오늄 카티온이다.〕

  本发明提供了一种含有比传统光敏碱发生剂对光更敏感的光敏碱发生剂和该光敏碱发生剂的感光性树脂组合物。 本发明是一种光敏碱发生剂，其具有含有一般式（1）所表示的盐的特征。 在一般式（1）中，R至R独立于彼此，表示如一般式（2）所示的基，该基是1至18个碳原子的烷基或芳基，但至少有一个基是表示为一般式（2）的基；在式（2）中，（D）表示至少有一个与硼元素结合的两个基，Ar与上述Ar相同；Q表示一个氧铵阳离子。
• [125I]Iododesethyl tamoxifen aziridine: Synthesis and covalent labeling of the estrogen receptor with an iodine-labeled affinity label
  作者：Francesco G. Salituro、Kathryn E. Carlson、Jonathan F. Elliston、Benita S. Katzenellenbogen、John A. Katzenellenbogen

  DOI：10.1016/0039-128x(86)90017-6

  日期：1986.11

  Iododesethyl tamoxifen aziridine (I-Tam-Az), an analog of the estrogen receptor-affinity label tamoxifen aziridine (Tam-Az) in which the ethyl group has been replaced by an iodine, has been prepared by two routes: (a) metallation of a bromotriarylethylene system, followed by reaction with iodine, and aziridinylation, and (b) direct iodination of a trimethylstannyl triarylethylene system that is the immediate precursor of I-Tam-Az. The latter method can be used to prepare [125I]I-Tam-Az rapidly and in good yield, both at carrier-added and no-carrier-added levels; specific activities greater than 200 Ci/mmol have been obtained. In competitive radiometric binding assays with the estrogen receptor, I-Tam-Az has an apparent affinity of ca. 20%, equivalent to that of Tam-Az. It also undergoes rapid and selective time-dependent, irreversible binding to the estrogen receptor. [125I]I-Tam-Az reacts covalently with estrogen receptor in uterine cytosol preparations; its attachment is rapid and efficient, but somewhat less selective than that of Tam-Az. Estrogen receptor in intact MCF-7 human breast cancer cells can also be labeled with [125I]I-Tam-Az, and autoradiographic analysis of salt extracts of labeled nuclear estrogen receptor on SDS-polyacrylamide slab gels shows highly selective labeling of a 65K protein. [125I]I-Tam-Az is an efficient, selective affinity label for the estrogen receptor, available at high specific activity, and should be useful in studies on estrogen receptor structure, dynamics, and chromatin interactions.