1-(4-(4-chlorobenzoyl)-5-(4-fluorophenyl)-2-methylfuran-3-yl)ethanone | 1651829-85-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(4-chlorobenzoyl)-5-(4-fluorophenyl)-2-methylfuran-3-yl)ethanone
• 英文别名: 1-[4-(4-Chlorobenzoyl)-5-(4-fluorophenyl)-2-methylfuran-3-yl]ethanone；1-[4-(4-chlorobenzoyl)-5-(4-fluorophenyl)-2-methylfuran-3-yl]ethanone
• CAS: 1651829-85-4
• 化学式: C₂₀H₁₄ClFO₃
• 分子量: 356.781
• InChiKey: KSHUVDIJLHUTPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  47.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(4-氯苯基)-3-(4-氟苯基)-2-丙烯-1-酮 、 乙酰丙酮 在 manganese(IV) oxide 、 溶剂黄146 、 zinc(II) chloride 作用下， 反应 24.0h， 以84%的产率得到1-(4-(4-chlorobenzoyl)-5-(4-fluorophenyl)-2-methylfuran-3-yl)ethanone
  参考文献：
  名称：

  1,3-二羰基化合物与α，β-不饱和酮的二氧化锰介导的氧化偶联：直接获得3,4-二羰基取代的呋喃

  摘要：

  AbstractAn efficient manganese dioxide‐mediated and highly selective oxidative CH/CH functionalization of 1,3‐dicarbonyl compounds with α,β‐unsaturated ketones for the construction of tetrasubstituted furans in one step has been demonstrated. This catalytic system converts two CH bonds and CO bonds to CC and CO bonds. This reaction provides a facile and regio‐defined method for the synthesis of 3,4‐dicarbonyl substituted furans.magnified image

  DOI：

  10.1002/adsc.201400097

文献信息

• Manganese Dioxide-Mediated Oxidative Coupling of 1,3-Dicarbonyl Compounds with α,β-Unsaturated Ketones: Direct Access to 3,4-Dicarbonyl Substituted Furans
  作者：Yuanyuan Yue、Yuanli Zhang、Weiwei Song、Xin Zhang、Jianming Liu、Kelei Zhuo

  DOI：10.1002/adsc.201400097

  日期：2014.8.11

  AbstractAn efficient manganese dioxide‐mediated and highly selective oxidative CH/CH functionalization of 1,3‐dicarbonyl compounds with α,β‐unsaturated ketones for the construction of tetrasubstituted furans in one step has been demonstrated. This catalytic system converts two CH bonds and CO bonds to CC and CO bonds. This reaction provides a facile and regio‐defined method for the synthesis of 3,4‐dicarbonyl substituted furans.magnified image