(E)-2,3-diethyl-2-methyloxirane | 14102-57-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: (E)-2,3-diethyl-2-methyloxirane
• 英文别名: (Z)-2,3-diethyl-2-methyloxirane；2,3-Diethyl-2-methyloxirane
• CAS: 14102-57-9
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: YKFDDISACQSCBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-2,3-diethyl-2-methyloxirane 在 正丁基锂 、 potassium tert-butylate 、 二异丙胺 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 生成 (E)-4-methyl-4-hexen-3-ol 、 2-ethyl-1-penten-3-ol
  参考文献：
  名称：

  混合金属碱可轻松将环氧乙烷酮异构化为烯丙醇

  摘要：

  二异丙基氨基化锂和叔丁醇钾（“ LIDAKOR试剂”）的混合物可促进环氧乙烷的平滑开环，从而以良好或优异的收率得到烯丙醇。内部环氧烷烃和大分子环氧环烷烃优先或仅产生反式链烯醇。开环反应的区域和立体化学本质上是顺-平面消除机理的结果。

  DOI：

  10.1016/s0040-4020(01)82021-4
• 作为产物：
  描述：

  (E)-3-甲基己-3-烯 在 二甲基二环氧乙烷 作用下， 以 丙酮 为溶剂， 生成 (E)-2,3-diethyl-2-methyloxirane
  参考文献：
  名称：

  二甲基二环氧乙烷对烯烃的环氧化：螺环过渡态的证据

  摘要：

  二甲基二环氧乙烷对烯烃进行环氧化的相对反应系列表明，该反应对位阻因素出乎意料的敏感。化合物的活性是同分异构体的约8倍。

  DOI：

  10.1016/s0040-4039(00)95499-6

文献信息

• TUMOR-TARGETING EVALUATION METHODOLOGY AND COMPOUNDS RELATED THERETO
  申请人：GOURDEAU Henriette

  公开号：US20090062255A1

  公开（公告）日：2009-03-05

  The invention relates to a method for evaluating a chemotherapeutic potential of a candidate molecule. In evaluating the candidate molecule, the candidate molecule is tested for its ability to inhibit the in vitro growth of a cancer cell; to bind a cellular receptor produced by a cancer cell, wherein said receptor, such as a peripheral benzodiazepine receptor, is produced in a greater amount by said cancer cell than by a normal cell; and to inhibit the activity of at least one protein member of the MAPK pathway. The invention further relates to dibenzodiazepinone analogues and derivatives thereof.

  该发明涉及一种评估候选分子化疗潜力的方法。在评估候选分子时，将测试候选分子抑制癌细胞体外生长的能力；结合由癌细胞产生的细胞受体，其中所述受体，如外周苯二氮卓受体，由所述癌细胞产生的数量比正常细胞多；并抑制MAPK通路中至少一个蛋白质成员的活性。该发明还涉及二苯二氮卓酮类似物及其衍生物。
• Farnesyl dibenzodiazepinone and processes for its production
  申请人：McAlpine James B.

  公开号：US20080199940A1

  公开（公告）日：2008-08-21

  This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.

  本发明涉及一种新型的法尼醇基二苯并二氮杂环酮，命名为ECO-04601，其药物可接受的盐和衍生物，以及获得这种化合物的方法。获得ECO-04601化合物的一种方法是通过培养一种新的微单孢菌株Micromonosporasp. 046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。本发明还涉及Micromonosporasp.株046-ECO11的使用，以及ECO-04601及其药物可接受的盐和衍生物作为药物的使用，特别是作为癌细胞生长抑制剂，细菌细胞生长抑制剂，哺乳动物脂氧合酶以及包含ECO-04601或其药物可接受的盐或衍生物的药物组合物。最后，本发明涉及新的多核苷酸序列及其编码的蛋白质，这些蛋白质参与ECO-04601的生物合成。
• MORDINI, ALESSANDRO;RAYANA, EZZEDINE BEN;MARGOT, CHRISTIAN;SCHLOSSER, MAN+, TETRAHEDRON, 46,(1990) N, C. 2401-2410
  作者：MORDINI, ALESSANDRO、RAYANA, EZZEDINE BEN、MARGOT, CHRISTIAN、SCHLOSSER, MAN+

  DOI：——

  日期：——
• Methods of making nanocomposites and compositions of rubber toughened polyhydroxyalkanoates
  申请人：Mohanty K. Amar

  公开号：US20070015858A1

  公开（公告）日：2007-01-18

  Toughened compositions from polyhydroxyalkanoate (PHA), preferably PHB reactively blended with maleated poly butadiene and with an epoxidized natural or synthetic rubber are described. The compositions preferably include clay nanoparticles which can be organically modified and can be exfoliated by the blend. The compositions can be used in a variety of applications, including automotive uses.
• METHOD FOR PRODUCING AN EPOXIDIZED NATURAL RUBBER, RUBBER COMPOSITION FOR TIRES, AND PNEUMATIC TIRE
  申请人：SUMITOMO RUBBER INDUSTRIES, LTD.

  公开号：US20140378619A1

  公开（公告）日：2014-12-25

  Provided are a method for producing a relatively uniformly epoxidized natural rubber in a simple and inexpensive manner, a rubber composition for tires that includes the epoxidized natural rubber, and a pneumatic tire formed from the rubber composition for tires. The present invention relates to a method for producing an epoxidized natural rubber, including: Step 1 of coagulating natural rubber latex into granules to prepare a granular solid rubber; and Step 2 of treating the granular solid rubber with an epoxidizing liquid to epoxidize the granular solid rubber.