Quinolinium, 1-(5-carboxypentyl)-4-methyl- | 769878-71-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Quinolinium, 1-(5-carboxypentyl)-4-methyl-
• 英文别名: 6-(4-methylquinolin-1-ium-1-yl)hexanoic acid
• CAS: 769878-71-9
• 化学式: C16H20NO2+
• 分子量: 258.33
• InChiKey: VKRDKQLQKNINNU-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  41.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes
  申请人：PROLIGO, LLC

  公开号：US20030143591A1

  公开（公告）日：2003-07-31

  The invention comprises novel methods and strategies to detect and/or quantify nucleic acid analytes. The methods involve nucleic acid probes with covalently conjugated dyes, which are attached either at adjacent nucleotides or at the same nucleotide of the probe and novel linker molecules to attach the dyes to the probes. The nucleic acid probes generate a fluorescent signal upon hybridization to complementary nucleic acids based on the interaction of one of the attached dyes, which is either an intercalator or a DNA groove binder, with the formed double stranded DNA. The methods can be applied to a variety of applications including homogeneous assays, real-time PCR monitoring, transcription assays, expression analysis on nucleic acid microarrays and other microarray applications such as genotyping (SNP analysis). The methods further include pH-sensitive nucleic acid probes that provide switchable fluorescence signals that are triggered by a change in the pH of the medium.

  该发明包括检测和/或定量核酸分析物的新方法和策略。这些方法涉及具有共价结合染料的核酸探针，这些染料附着在探针的相邻核苷酸或同一核苷酸上，并涉及用于将染料连接到探针的新型连接分子。核酸探针在与互补核酸杂交时产生荧光信号，基于附着的染料之一（可以是插入剂或DNA沟结合剂）与形成的双链DNA的相互作用。这些方法可应用于各种应用，包括均相分析、实时PCR监测、转录分析、核酸微阵列上的表达分析以及其他微阵列应用，如基因分型（SNP分析）。该方法还包括pH敏感的核酸探针，提供可通过介质pH变化触发的可切换荧光信号。
• Methods for detecting the presence, location or quantity of targets using novel dyes
  申请人：Xiang Yuejun

  公开号：US20100041020A1

  公开（公告）日：2010-02-18

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，例如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料连接到将结合到所需目标分子的探针上。本发明的新型染料已通过添加带电和极性基团进行改性，以提供有益的性质。
• Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes
  申请人：Xiang Yuejun

  公开号：US20120040430A1

  公开（公告）日：2012-02-16

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，例如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料已通过添加带电和极性基团进行改性，以提供有益的性质。
• WATER SOLUBLE FLUORESCENT COMPOUNDS
  申请人：REDDINGTON MARK

  公开号：US20110294118A1

  公开（公告）日：2011-12-01

  The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.

  本发明提供了一种新型荧光化合物。还提供了荧光化合物的结合物，使用荧光化合物及其结合物的方法以及包括荧光化合物及其结合物的试剂盒。
• Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules
  申请人：Xiang Yuejun

  公开号：US20100228008A1

  公开（公告）日：2010-09-09

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号发生。还提供了包含反应基团的染料，可用于将染料附着到探针上，以结合所需的目标分子。本发明的新型染料经过修饰，添加了带电和极性基团，以提供有益的性质。