4-Acetoxychinolin | 30074-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Acetoxychinolin
• 英文别名: Quinolin-4-yl acetate
• CAS: 30074-80-7
• 化学式: C₁₁H₉NO₂
• 分子量: 187.198
• InChiKey: YKXVFWUHKKGVMU-UHFFFAOYSA-N

物化性质

• 沸点：
  321.6±15.0 °C(Predicted)
• 密度：
  1.212±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Acetoxychinolin 在 2-甲基四氢呋喃 、 tris-(dibenzylideneacetone)dipalladium(0) 、 2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl 、 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 20.0h， 生成 4-(p-aminophenyl)-quinoline
  参考文献：
  名称：

  Method of fluorination using iodonium ylides

  摘要：

  描述了一种使用碘化亚烯并适用于使用18F进行放射性氟化的芳香化合物氟化的过程。描述了过程、中间体、试剂和标记化合物。

  公开号：

  US10259800B2
• 作为产物：
  描述：

  4-羟基喹啉 、 乙酰氯 在 N-乙基吗啉 作用下， 以 二氯甲烷 为溶剂， 以38 %的产率得到4-Acetoxychinolin
  参考文献：
  名称：

  N-杂芳烃与硅烷羧酸的脱羧 C-H 硅烷化

  摘要：

  已建立的脱羧 Minisci 反应仅限于脂肪族羧酸，因为它们的类似物硅烷羧酸很少被研究。在此，我们提出了一种新的 N-杂芳烃与硅烷羧酸在光介导或银介导条件下的脱羧 Minisci 型反应。这种 C-H 硅烷化策略以中等到优异的产率和高区域选择性提供了多种 N-杂芳基硅烷的有效途径，其中 Ag 催化的硅烷羧酸脱羧提供了一种前所未有的甲硅烷基自由基生成方法。

  DOI：

  10.1039/d2cc06380h

文献信息

• Novel Mesoionic Insecticidal Compound
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：US20200017490A1

  公开（公告）日：2020-01-16

  The purpose of the present invention is to provide a mesoionic compound, which exhibits an improved controlling effect on various harmful organisms, or a salt thereof. A mesoionic compound represented by formula (1) (wherein: R 1 is selected from a hydrogen atom, etc.; R 2 represents an optionally substituted phenyl group; R 3 is selected from a hydrogen atom, etc.; R 4 is selected from a hydrogen atom, etc.; R 5 is selected from an optionally substituted ethylene group, etc.; and X is selected from an oxygen atom, etc.) or a salt thereof.

  本发明的目的是提供一种嵌环离子化合物，其在各种有害生物上表现出改进的控制效果，或其盐。由式（1）表示的嵌环离子化合物（其中：R1选自氢原子等；R2代表可选择取代的苯基团；R3选自氢原子等；R4选自氢原子等；R5选自可选择取代的乙烯基团等；X选自氧原子等）或其盐。
• Mesoionic Compound
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：US20180310564A1

  公开（公告）日：2018-11-01

  The purpose of the present invention is to provide a mesoionic compound or a salt thereof that exhibits excellent control activity against various pests. Provided is a mesoionic compound represented by formula (1). (In the formula, Ra represents a hydrogen atom or a methyl group, R 1 represents a phenyl group or pyridyl group which is optionally substituted with up to two substituents selected independently from R 2 , and R 2 represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, a methyl group, an ethyl group, an n-propyl group, an i-propyl group, a c-propyl group, an n-butyl group, an i-butyl group, an s-butyl group, a t-butyl group, a fluoromethyl group, a difluoromethyl group, a trifluoromethyl group, a methyloxy group, an ethyloxy group, an n-propyloxy group, an i-propyloxy group, a c-propyloxy group, an n-butyloxy group, an i-butyloxy group, a s-butyloxy group, a t-butyloxy group, an n-pentyloxy group, a trifluoromethyloxy group, a 2,2,2-trifluoroethyloxy group, a methylthio group, a methylsulfoxy group, a methylsulfonyl group, a vinyl group, an ethynyl group, etc.)

  本发明的目的是提供一种对各种害虫具有出色控制活性的噻唑离子化合物或其盐。提供了由式(1)表示的噻唑离子化合物。（在该式中，Ra代表氢原子或甲基基团，R1代表苯基或吡啶基，可选地取代高达两个从R2中独立选择的取代基，R2代表氢原子、氟原子、氯原子、溴原子、甲基基团、乙基基团、正丙基基团、异丙基基团、叔丙基基团、正丁基基团、异丁基基团、对丁基基团、叔丁基基团、氟甲基基团、二氟甲基基团、三氟甲基基团、甲氧基基团、乙氧基基团、正丙氧基基团、异丙氧基基团、叔丙氧基基团、正丁氧基基团、异丁氧基基团、对丁氧基基团、叔丁氧基基团、正戊氧基基团、三氟甲氧基基团、2,2,2-三氟乙氧基基团、甲硫基基团、甲磺氧基基团、甲磺酰基基团、乙烯基团、乙炔基团等。）
• AMIDE DERIVATIVE
  申请人：Nakahira Hiroyuki

  公开号：US20100056497A1

  公开（公告）日：2010-03-04

  The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R 1a is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.; R 1b is an optionally substituted C 1-6 alkoxy, etc.; R 1c is a hydrogen atom, an optionally substituted C 1-6 alkoxy, etc.; R 2 is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3c and R 3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, —(CH 2 ) s O—, —(CH 2 ) s N(R 4 )CO—, etc., B is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.), etc.; R 4 is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.

  本发明涉及一种具有式(I)的化合物，其可用作肾素抑制剂，或其药学上可接受的盐。其中，R1a是氢原子，可选地取代的C1-6烷基等；R1b是可选地取代的C1-6烷氧基等；R1c是氢原子，可选地取代的C1-6烷氧基等；R2是氢原子，可选地取代的C1-6烷基等；R3a，R3b，R3c和R3d独立且相同或不同，每个是式：-A-B的基团（其中A是单键，-(CH2)sO-，-(CH2)sN(R4)CO-等，B是氢原子，可选地取代的C1-6烷基等）等；R4是氢原子，可选地取代的C1-6烷基等；s为0等；n为1等。
• [1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF
  申请人：Duan Wenhu

  公开号：US20130324542A1

  公开（公告）日：2013-12-05

  The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition including a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.

  本发明涉及结构新颖的[1,2,4]三唑并[4,3-b][1,2,4]三嗪化合物，其化学式为(I)或(II)，其药学上可接受的盐、前药、水合物或溶剂化物，以及化合物的制备方法、包括治疗有效量的化合物的制药组合物，以及其作为蛋白酪氨酸激酶抑制剂，特别是作为c-Met抑制剂，在制备与c-Met异常相关的疾病的药物的预防和/或治疗中的用途。
• [1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUND, PREPARATION METHOD AND USE THEREOF
  申请人：Shanghai Institute Materia Medica, Chinese Academy Of Sciences

  公开号：EP2650293A1

  公开（公告）日：2013-10-16

  The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition comprising a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.

  本发明涉及一种结构新颖的由式(I)或式(II)表示的[1,2,4]三唑并[4,3-b][1,2,4]三嗪化合物、其药学上可接受的盐、其原药、其水合物或溶液，还涉及该化合物的制备方法、一种包含治疗有效量化合物的药物组合物，以及其作为蛋白酪氨酸激酶抑制剂，特别是作为 c-Met 抑制剂在制备预防和/或治疗与 c-Met 异常相关疾病的药物中的用途。