N-methyl-5,6,7,8-tetrahydroisoquinolin-8-amine | 497251-67-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-methyl-5,6,7,8-tetrahydroisoquinolin-8-amine
• CAS: 497251-67-9
• 化学式: C₁₀H₁₄N₂
• 分子量: 162.235
• InChiKey: DIHABIJGJRTAET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-5,6,7,8-tetrahydroisoquinolin-8-amine 在 lithium aluminium tetrahydride 作用下， 生成 N-ethyl-N-methyl-5,6,7,8-tetrahydroisoquinolin-8-amine
  参考文献：
  名称：

  (±)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents

  摘要：

  Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.020
• 作为产物：
  描述：

  5,6,7,8-四氢-8-异喹啉醇 在 氯化亚砜 作用下， 生成 N-methyl-5,6,7,8-tetrahydroisoquinolin-8-amine
  参考文献：
  名称：

  (±)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents

  摘要：

  Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.020

文献信息

• (±)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents
  作者：Małgorzata Dukat、Mohamed Taroua、Abdelaziz Dahdouh、Umamaheswar Siripurapu、M Imad Damaj、Billy R Martin、Richard A Glennon

  DOI：10.1016/j.bmcl.2004.05.020

  日期：2004.7

  Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown. (C) 2004 Elsevier Ltd. All rights reserved.