(2I+/-,3I+/-,4I(2))-2,3-Dihydroxyurs-12-en-23-oic acid | 164920-64-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2I+/-,3I+/-,4I(2))-2,3-Dihydroxyurs-12-en-23-oic acid
• 英文别名: (2R,3S,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-2,3-dihydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid
• CAS: 164920-64-3
• 化学式: C₃₀H₄₈O₄
• 分子量: 472.7
• InChiKey: CAQINDLNYJDVHH-YZRPLIBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  34
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Compositions of boswellic acids derived from Boswellia serrata gum resin, for treating lymphoproliferative and autoimmune conditions
  申请人：Majeed Muhammed

  公开号：US20060234990A1

  公开（公告）日：2006-10-19

  A method of treatment of lymphoproliferative and autoimmune disorders with a new composition of four boswellic acids including β-boswellic acid, 3-O-acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-β-boswellic acid. Boswellic acids of invention have been obtained in a novel industrial process from the gum resin of Boswellia serrata tree, providing standardized composition which inhibits DNA, RNA and protein synthesis of the target cell without cytotoxic effects. The composition of invention provides advantage of irreversible cytostatic therapy, equivalent to biological effects of a cytotoxic therapy without killing body cells.

  一种用四种乳香酸（包括β-乳香酸、3-O-乙酰基-β-乳香酸、11-酮-β-乳香酸和3-O-乙酰基-11-酮-β-乳香酸）组成的新组合物治疗淋巴增生性疾病和自身免疫性疾病的方法。本发明的乳香酸是通过一种新型工业工艺从 乳香树 本发明的乳香酸是从乳香树胶树脂中以新颖的工业工艺获得的，提供的标准化成分可抑制靶细胞的 DNA、RNA 和蛋白质合成，且无细胞毒性作用。本发明的组合物具有不可逆细胞抑制疗法的优势，相当于细胞毒性疗法的生物效应，但不会杀死人体细胞。
• COMPOSITIONS OF BOSWELLIC ACIDS DERIVED FROM BOSWELLIA SERRATA GUM RESIN, FOR TREATING LYMPHOPROLIFERATIVE AND AUTOIMMUNE CONDITIONS
  申请人：Sabinsa Corporation

  公开号：EP1173162A1

  公开（公告）日：2002-01-23
• [EN] COMPOSITIONS OF BOSWELLIC ACIDS DERIVED FROM BOSWELLIA SERRATA GUM RESIN, FOR TREATING LYMPHOPROLIFERATIVE AND AUTOIMMUNE CONDITIONS<br/>[FR] COMPOSITIONS A BASE D'ACIDES BOSWELLIQUES, DERIVEES DE GOMME-RESINE DE BOSWELLIA SERRATA ET DESTINEES A TRAITER DES ETATS LYMPHOPROLIFERATIFS ET AUTO-IMMUNS
  申请人：SABINSA CORP

  公开号：WO2000066111A1

  公开（公告）日：2000-11-09

  Method of treatment of lymphoproliferative and autoimmune disorders with a new composition of four boswellic acids including β-boswellic acid, 3-O-acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-β-boswellic acid. Boswellic acids of invention have been obtained in a novel industrial process from the gum resin of Boswellia serrata tree, providing standardized composition which inhibits DNA, RNA and protein synthesis of the target cell without cytotoxic effects. Composition of invention provides advantage of irreversible cytostatic therapy, equivalent to biological effects of a cytotoxic therapy without killing body cells.