[10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl]triphenylphosphonium, monomethanesulfonate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl]triphenylphosphonium, monomethanesulfonate
• 英文别名: purinostat mesylate；10-(4,5-dimethoxy-2-methyl-3,6-dihydroxy-1,4-cyclohexadienyl)decyl-triphenylphosphonium mesylate；mitoquinol；mitoquinol mesylate；[10-(3,6-dihydroxy-4,5-dimethoxy-2-methylphenyl)decyl]triphenylphosphonium methane sulfonate；MitoQ；4-hydroxy-2,3-dimethoxy-6-methyl-5-(10-triphenylphosphaniumyldecyl)phenolate;methanesulfonic acid
• 化学式: CH₃O₃S*C₃₇H₄₆O₄P
• 分子量: 680.843
• InChiKey: WPMXVYGZUOSRAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.24
• 重原子数：
  47
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  [10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl]triphenylphosphonium, monomethanesulfonate 以94的产率得到米托蒽醌甲磺酸盐
  参考文献：
  名称：

  Mitoquinone derivatives used as mitochondrially targeted antioxidants

  摘要：

  本发明涉及药学上可接受的两性亲水抗氧化剂化合物、包含该化合物的组合物和剂型，以及依赖于该化合物的方法和用途。所示的化合物都是丙酮酸脱氢酶抑制剂衍生物，是甲氧基苯基烷基三苯基膦或甲氧基二氧杂环己二烯烷基三苯基膦衍生物。该化合物、组合物、剂型、用途和方法在治疗与氧化应激有关的疾病或病况方面是有用的。

  公开号：

  US07888335B2
• 作为产物：
  描述：

  idebenol mesylate 以89的产率得到[10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl]triphenylphosphonium, monomethanesulfonate
  参考文献：
  名称：

  Mitoquinone derivatives used as mitochondrially targeted antioxidants

  摘要：

  本发明涉及药学上可接受的两性亲水抗氧化剂化合物、包含该化合物的组合物和剂型，以及依赖于该化合物的方法和用途。所示的化合物都是丙酮酸脱氢酶抑制剂衍生物，是甲氧基苯基烷基三苯基膦或甲氧基二氧杂环己二烯烷基三苯基膦衍生物。该化合物、组合物、剂型、用途和方法在治疗与氧化应激有关的疾病或病况方面是有用的。

  公开号：

  US07888335B2

文献信息

• Mitoquinone derivatives used as mitochondrially targeted antioxidants
  申请人：Antipodean Pharmaceuticals, Inc.

  公开号：US07888335B2

  公开（公告）日：2011-02-15

  This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.

  本发明涉及药学上可接受的两性亲水抗氧化剂化合物、包含该化合物的组合物和剂型，以及依赖于该化合物的方法和用途。所示的化合物都是丙酮酸脱氢酶抑制剂衍生物，是甲氧基苯基烷基三苯基膦或甲氧基二氧杂环己二烯烷基三苯基膦衍生物。该化合物、组合物、剂型、用途和方法在治疗与氧化应激有关的疾病或病况方面是有用的。
• Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologies
  作者：Gang Cheng、Hakim Karoui、Micael Hardy、Balaraman Kalyanaraman

  DOI：10.1016/j.freeradbiomed.2023.06.009

  日期：2023.8
• MITOCHONDRIALLY TARGETED ANTIOXIDANTS IN THE TREATMENT OF LIVER DISEASES AND EPITHELIAL CANCERS
  申请人：Oridis Biomed Forschungs- und Entwicklungs GmbH

  公开号：EP1765413A2

  公开（公告）日：2007-03-28
• Use of mitochondrially targeted antioxidant in treatment and prevention of drug-induced liver disease
  申请人：Buck Charles

  公开号：US20070161609A1

  公开（公告）日：2007-07-12

  The present invention relates to the method of treatment or prophylaxis of patients with drug-induced liver diseases which comprises administering to the patient in need thereof a therapeutically effective amount of a mitochondrially targeted antioxidant compound e.g. derivatives of vitamin E, coenzyme Q 10 or a glutathione peroxidase mimetic. The present invention also relates to pharmaceutical compositions containing the antioxidant(s) intended for such use.
• Use of Mitochondrially Targeted Antioxidant in the Treatment of Liver Diseases and Epithelial Cancers
  申请人：Frohlich Eleonore

  公开号：US20070225255A1

  公开（公告）日：2007-09-27

  The present invention relates to the use of a mitochondrially targeted antioxidant, e.g. derivatives of vitamin E, coenzyme Q 10 or a glutathione peroxidase mimetic, in the treatment and prevention of liver diseases and/or epithelial cancers. The present invention also relates to pharmaceutical compositions containing the antioxidant(s) intended for such use. Furthermore the invention relates to the manufacture of medicaments containing the antioxidant(s) useful for such prevention and treatment.