(2aS,2bR,5aS,6aR)-2a-Methyl-4-methylene-6-oxo-octahydro-cyclobuta[a]pentalene-6a-carboxylic acid ethyl ester | 863714-71-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2aS,2bR,5aS,6aR)-2a-Methyl-4-methylene-6-oxo-octahydro-cyclobuta[a]pentalene-6a-carboxylic acid ethyl ester
• 英文别名: ethyl (1R,2S,5R,7S)-2-methyl-9-methylidene-6-oxotricyclo[5.3.0.02,5]decane-5-carboxylate
• CAS: 863714-71-0
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: XVEVOHWBEULRGA-IDTSFGKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2aS,2bR,5aS,6aR)-2a-Methyl-4-methylene-6-oxo-octahydro-cyclobuta[a]pentalene-6a-carboxylic acid ethyl ester 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以53%的产率得到(2aS,2bR,5aS,6R,6aR)-6-Hydroxy-2a-methyl-4-methylene-octahydro-cyclobuta[a]pentalene-6a-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis of (+)-Sulcatine G

  摘要：

  The total synthesis of (+)-sulcatine G is described. A key structural feature of sulcatine G is the highly functionalized, enantiomerically pure cyclobutane ring. We have prepared (+)-sulcatine G using a new strategy for bicyclic ring construction, Rh-mediated intramolecular C-H insertion followed by intramolecular alkylation.

  DOI：

  10.1021/jo0508752
• 作为产物：
  描述：

  (1R,5S)-5-Methyl-2-oxo-bicyclo[3.2.0]heptane-1-carboxylic acid ethyl ester 在 正丁基锂 、 4-dimethylaminopyridine tribromide 、 三异丙基亚磷酸酯 、 palladium diacetate 、 溶剂黄146 、 calcium carbonate 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 (2aS,2bR,5aS,6aR)-2a-Methyl-4-methylene-6-oxo-octahydro-cyclobuta[a]pentalene-6a-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis of (+)-Sulcatine G

  摘要：

  The total synthesis of (+)-sulcatine G is described. A key structural feature of sulcatine G is the highly functionalized, enantiomerically pure cyclobutane ring. We have prepared (+)-sulcatine G using a new strategy for bicyclic ring construction, Rh-mediated intramolecular C-H insertion followed by intramolecular alkylation.

  DOI：

  10.1021/jo0508752

文献信息

• Synthesis of (+)-Sulcatine G
  作者：Douglass F. Taber、Kevin J. Frankowski

  DOI：10.1021/jo0508752

  日期：2005.8.1

  The total synthesis of (+)-sulcatine G is described. A key structural feature of sulcatine G is the highly functionalized, enantiomerically pure cyclobutane ring. We have prepared (+)-sulcatine G using a new strategy for bicyclic ring construction, Rh-mediated intramolecular C-H insertion followed by intramolecular alkylation.