(1S,2R,3R,4R,8R,10S)-4-methyl-6-azatetracyclo[6.3.0.02,6.03,10]undecane | 144220-48-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S,2R,3R,4R,8R,10S)-4-methyl-6-azatetracyclo[6.3.0.02,6.03,10]undecane
• CAS: 144220-48-4
• 化学式: C₁₁H₁₇N
• 分子量: 163.263
• InChiKey: AATNDAGWWCIDRG-LSGFFFPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  二氯甲烷 、 (1S,2R,3R,4R,8R,10S)-4-methyl-6-azatetracyclo[6.3.0.02,6.03,10]undecane 以91%的产率得到
  参考文献：
  名称：

  Cyclisation of aminyl radicals using sulfenamide precursors

  摘要：

  Sulfenamides react readily with tributyltin hydride to yield aminyl radicals, which undergo intramolecular addition to activated double bonds.

  DOI：

  10.1016/s0040-4039(00)61254-6
• 作为产物：
  描述：

  N-allyl-(bicyclo<2.2.1>hept-5-en-2-yl)methylamine 在 sodium tetrahydroborate 、 mercury dichloride 作用下， 生成 (1S,2R,3R,4R,8R,10S)-4-methyl-6-azatetracyclo[6.3.0.02,6.03,10]undecane
  参考文献：
  名称：

  Cyclisation of aminyl radicals using sulfenamide precursors

  摘要：

  Sulfenamides react readily with tributyltin hydride to yield aminyl radicals, which undergo intramolecular addition to activated double bonds.

  DOI：

  10.1016/s0040-4039(00)61254-6

文献信息

• Synthesis of pyrrolizidines using aminyl radicals generated from sulfenamide precursors
  作者：W.Russell Bowman、David N. Clark、Robert J. Marmon

  DOI：10.1016/s0040-4020(01)80838-3

  日期：1994.1

  Tandem radical cyclisations of aminyl radicals generated from sulfenamide precursors have been used for the synthesis of pyrrolizidines and other polycyclic nitrogen heterocycles. The aminyl radicals are generated by reaction between sulfenamide precursors and Bu3SnH.

  由亚磺酰胺前体产生的氨基自由基的串联自由基环化已用于合成吡咯烷核苷和其他多环氮杂环。通过亚磺酰胺前体与Bu 3 SnH之间的反应来生成胺基。
• Cyclisation of aminyl radicals using sulfenamide precursors
  作者：W.Russell Bowman、David N. Clark、Robert J. Marmon

  DOI：10.1016/s0040-4039(00)61254-6

  日期：1992.8

  Sulfenamides react readily with tributyltin hydride to yield aminyl radicals, which undergo intramolecular addition to activated double bonds.