cyclokirilodiol | 188725-44-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: cyclokirilodiol
• 英文别名: (3S,5S)-5-[(1S)-1-[(1S,3R,6S,8R,11S,12S,15R,16R)-6-hydroxy-7,7,12,16-tetramethyl-15-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]ethyl]-2,2-dimethyloxolan-3-ol
• CAS: 188725-44-2
• 化学式: C₃₀H₅₀O₃
• 分子量: 458.725
• InChiKey: MCQQYOJCESNCDO-FAFMSXLASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  33
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  cyclokirilodiyl diacetate 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 以96%的产率得到cyclokirilodiol
  参考文献：
  名称：

  Cyclokirilodiol and Isocyclokirilodiol: Two Novel Cycloartanes from the Seeds of Trichosanthes kirilowii MAXIM.

  摘要：

  Two novel cycloartane-type triterpene alcohols possessing a monohydroxy-tetrahydrofuran ring in the side chain, cyclokirilodiol and isocyclokirilodiol, were isolated from the nonsaponifiable lipid fraction obtained from the methanolic extract of Trichosanthes kirilowii seeds. Their structures were determined as (22S, 24S)-22, 25-epoxy-24-hydroxy-5α-cycloartan-3β-ol and (22R, 24S)-22, 25-epoxy-24-hydroxy-5α-cycloartan-3β-ol, respectively, by detailed spectroscopic analyses.

  DOI：

  10.1248/cpb.45.415

文献信息

• Cyclokirilodiol and Isocyclokirilodiol: Two Novel Cycloartanes from the Seeds of Trichosanthes kirilowii MAXIM.
  作者：Yumiko KIMURA、Toshihiro AKIHISA、Ken YASUKAWA、Sei-ichi TAKASE、Toshitake TAMURA、Yoshiteru IDA

  DOI：10.1248/cpb.45.415

  日期：——

  Two novel cycloartane-type triterpene alcohols possessing a monohydroxy-tetrahydrofuran ring in the side chain, cyclokirilodiol and isocyclokirilodiol, were isolated from the nonsaponifiable lipid fraction obtained from the methanolic extract of Trichosanthes kirilowii seeds. Their structures were determined as (22S, 24S)-22, 25-epoxy-24-hydroxy-5α-cycloartan-3β-ol and (22R, 24S)-22, 25-epoxy-24-hydroxy-5α-cycloartan-3β-ol, respectively, by detailed spectroscopic analyses.