6-acetyl-7-(2-dimethylaminovinyl)-2-phenylpyrazolo<1,5-a>pyrimidine | 147196-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-acetyl-7-(2-dimethylaminovinyl)-2-phenylpyrazolo<1,5-a>pyrimidine
• 英文别名: 1-[7-[2-(dimethylamino)ethenyl]-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl]ethanone
• CAS: 147196-34-7
• 化学式: C₁₈H₁₈N₄O
• 分子量: 306.367
• InChiKey: HHCLIJWIOPUWGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  50.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-acetyl-7-(2-dimethylaminovinyl)-2-phenylpyrazolo<1,5-a>pyrimidine 在 potassium carbonate 、 一水合肼 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 6-methyl-2-phenyl-8-(2-chloroethyl)pyrazolo<5',1':2,3>pyrimido<5,4-d><1,2>diazepine
  参考文献：
  名称：

  8H-Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepine: A New Tricyclic System

  摘要：

  Starting from a series of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines (2a-g), several derivatives of the pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepine system (3a-g) were obtained by reaction with hydrazine hydrate. Some compounds were finally alkylated at N -8 position.

  DOI：

  10.3987/com-92-6166
• 作为产物：
  描述：

  N,N-二甲基甲酰胺二甲基缩醛 、 1-(2-phenyl-7-methylpyrazolo<1,5-a>pyrimidin-6-yl)ethan-1-one 在 哌啶 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以66%的产率得到6-acetyl-7-(2-dimethylaminovinyl)-2-phenylpyrazolo<1,5-a>pyrimidine
  参考文献：
  名称：

  8H-Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepine: A New Tricyclic System

  摘要：

  Starting from a series of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines (2a-g), several derivatives of the pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepine system (3a-g) were obtained by reaction with hydrazine hydrate. Some compounds were finally alkylated at N -8 position.

  DOI：

  10.3987/com-92-6166

文献信息

• Reactivity of 7-(2-dimethylaminovinyl)pyrazolo[1,5-<i>a</i>]pyrimidines: Synthesis of pyrazolo[1,5-<i>a</i>]pyrido[3,4-<i>e</i>]pyrimidine derivatives as potential benzodiazepine receptor ligands.<b>1</b>
  作者：Fabrizio Bruni、Silvia Selleri、Annarella Costanzo、Gabriella Guerrini、Maria Lucia Casilli

  DOI：10.1002/jhet.5570310516

  日期：1994.9

  of 7-methylpyrazolo[1,5-a]pyrimidines were reacted with dimethylformamide dimethylacetal to give the corresponding dimethylaminovinyl derivatives. These were reacted with ammonium acetate affording, through a ring closure, a number of 6-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidines bearing various substituents on the pyrazole ring. The 6-acetyl-2-hydroxy-7-methylpyrazolo[1,5-a]pyrimidine was used as

  使一系列的7-甲基吡唑并[1，5- a ]嘧啶与二甲基甲酰胺二甲基乙缩醛反应，得到相应的二甲基氨基乙烯基衍生物。它们与乙酸铵反应，通过闭环反应，得到许多在吡唑环上带有各种取代基的6-甲基吡唑并[ 1,5- a ]吡啶基[3,4- e ]嘧啶。将6-乙酰基-2-羟基-7-甲基吡唑并[1，5- a ]嘧啶用作起始原料，以获得一些O-烷基衍生物。2-苄氧基-6-甲基吡唑并[ 1,5- a ]吡啶基[3,4- e ]嘧啶的催化转移氢化反应生成了2-羟基衍生物。