2,2,2-Trichloro-1-(2,4-dimethylquinolin-3-yl)ethanone | 1418740-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2,2-Trichloro-1-(2,4-dimethylquinolin-3-yl)ethanone
• 英文别名: 2,2,2-trichloro-1-(2,4-dimethylquinolin-3-yl)ethanone
• CAS: 1418740-98-3
• 化学式: C₁₃H₁₀Cl₃NO
• 分子量: 302.588
• InChiKey: ZRWIRTHKIVYION-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻氨基苯乙酮 、 1,1,1-trichloro-4-methoxy-3-penten-2-one 在 对甲苯磺酸 、 1-methylimidazolium p-toluenesulfonate 作用下， 反应 0.17h， 以91%的产率得到2,2,2-Trichloro-1-(2,4-dimethylquinolin-3-yl)ethanone
  参考文献：
  名称：

  Synthesis of novel quinolines using TsOH/ionic liquid under microwave

  摘要：

  In this work, 3-haloacetyl-4-methylquinolines were synthesized from the reaction of 4-alkoxy-3-alken-2-ones [(RC)-C-1(O)CH=C(R-2)OCH3, where R-1 = CF3, CCl3, CHCl2, CF2Cl, CF2CF3 and R-2 = Me, Et, Pr, Bu, i-Bu and i-Pe] and 2-aminoacetophenone. The reaction was performed in ionic liquid and 4-toluene sulfonic acid under microwave irradiation. Results showed that the catalytic method was effective. Products were formed in a short time (10-20 min) and presented good yields (70-91%).

  DOI：

  10.1590/s0103-50532012005000030

文献信息

• Synthesis of novel quinolines using TsOH/ionic liquid under microwave
  作者：Liziê D. T. Prola、Lilian Buriol、Clarissa P. Frizzo、Guilherme S. Caleffi、Mara R. B. Marzari、Dayse N. Moreira、Helio G. Bonacorso、Nilo Zanatta、Marcos A. P. Martins

  DOI：10.1590/s0103-50532012005000030

  日期：——

  In this work, 3-haloacetyl-4-methylquinolines were synthesized from the reaction of 4-alkoxy-3-alken-2-ones [(RC)-C-1(O)CH=C(R-2)OCH3, where R-1 = CF3, CCl3, CHCl2, CF2Cl, CF2CF3 and R-2 = Me, Et, Pr, Bu, i-Bu and i-Pe] and 2-aminoacetophenone. The reaction was performed in ionic liquid and 4-toluene sulfonic acid under microwave irradiation. Results showed that the catalytic method was effective. Products were formed in a short time (10-20 min) and presented good yields (70-91%).