(E,2S,5R)-5-methyl-2-(2-methylbutan-2-yl)-N-prop-2-enoxycyclohexan-1-imine | 1416450-42-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (E,2S,5R)-5-methyl-2-(2-methylbutan-2-yl)-N-prop-2-enoxycyclohexan-1-imine
• CAS: 1416450-42-4
• 化学式: C₁₅H₂₇NO
• 分子量: 237.385
• InChiKey: MHHYRPOUFSDADV-NDCYMYPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (dibenzoyloxyiodo)benzene 、 (E,2S,5R)-5-methyl-2-(2-methylbutan-2-yl)-N-prop-2-enoxycyclohexan-1-imine 在 PdCl₂(PhCN)2 作用下， 以 甲苯 为溶剂， 反应 8.0h， 生成 、
  参考文献：
  名称：

  Asymmetric Chiral Ligand-Directed Alkene Dioxygenation

  摘要：

  A Pd-catalyzed asymmetric alkene 1,2-dioxygenation reaction is described. The diastereoselectivity of the reaction is controlled by tethering a chiral oxime ether directing group to the alkene substrate. The best selectivities are obtained with 8-substituted menthone-derived oxime ether auxiliaries.

  DOI：

  10.1021/ol303003g
• 作为产物：
  描述：

  长叶薄荷酮 在 吡啶 、 copper(I) bromide 作用下， 生成 (E,2S,5R)-5-methyl-2-(2-methylbutan-2-yl)-N-prop-2-enoxycyclohexan-1-imine
  参考文献：
  名称：

  Asymmetric Chiral Ligand-Directed Alkene Dioxygenation

  摘要：

  A Pd-catalyzed asymmetric alkene 1,2-dioxygenation reaction is described. The diastereoselectivity of the reaction is controlled by tethering a chiral oxime ether directing group to the alkene substrate. The best selectivities are obtained with 8-substituted menthone-derived oxime ether auxiliaries.

  DOI：

  10.1021/ol303003g

文献信息

• Asymmetric Chiral Ligand-Directed Alkene Dioxygenation
  作者：Sharon R. Neufeldt、Melanie S. Sanford

  DOI：10.1021/ol303003g

  日期：2013.1.4

  A Pd-catalyzed asymmetric alkene 1,2-dioxygenation reaction is described. The diastereoselectivity of the reaction is controlled by tethering a chiral oxime ether directing group to the alkene substrate. The best selectivities are obtained with 8-substituted menthone-derived oxime ether auxiliaries.