1-Benzoyl-2-(2-oxopropyl)-cyclohexan | 58337-94-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Benzoyl-2-(2-oxopropyl)-cyclohexan
• 英文别名: 1-(2-Benzoylcyclohexyl)propan-2-one；1-(2-benzoylcyclohexyl)propan-2-one
• CAS: 58337-94-3
• 化学式: C₁₆H₂₀O₂
• 分子量: 244.334
• InChiKey: VGTLLILBANDNAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (2E,7E)-1-phenyldeca-2,7-diene-1,9-dione 在 platinum(II) chloride 氢气 、 tin(ll) chloride 作用下， 以 1,2-二氯乙烷 为溶剂， 80.0 ℃ 、101.33 kPa 条件下， 反应 2.0h， 生成 2-(2-Acetyl-cyclohexyl)-1-phenyl-ethanone 、 1-Benzoyl-2-(2-oxopropyl)-cyclohexan
  参考文献：
  名称：

  Platinum-catalyzed reductive coupling of activated alkenes under hydrogenation conditions

  摘要：

  The Pt complex generated from PtCl(2), PR(3), and SnCl(2) catalyzes the reductive coupling of activated alkenes under environmentally benign hydrogenation conditions. Various bis-enones participated in the intramolecular cyclization, forming the desired cyclization products in moderate to good yield. Intermolecular reductive coupling of the enone and the aldehyde provided the coupling product in good yield. This methodology illustrates the first use of platinum complexes in hydrogen-mediated couplings of activated alkenes. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.07.117

文献信息

• Platinum-catalyzed reductive coupling of activated alkenes under hydrogenation conditions
  作者：Harim Lee、Min-Soo Jang、Jong-Tai Hong、Hye-Young Jang

  DOI：10.1016/j.tetlet.2008.07.117

  日期：2008.9

  The Pt complex generated from PtCl(2), PR(3), and SnCl(2) catalyzes the reductive coupling of activated alkenes under environmentally benign hydrogenation conditions. Various bis-enones participated in the intramolecular cyclization, forming the desired cyclization products in moderate to good yield. Intermolecular reductive coupling of the enone and the aldehyde provided the coupling product in good yield. This methodology illustrates the first use of platinum complexes in hydrogen-mediated couplings of activated alkenes. (C) 2008 Elsevier Ltd. All rights reserved.