3-乙酰基环戊烷羧酸 | 214531-78-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-乙酰基环戊烷羧酸
• 英文名称: 3-acetyl-cyclopentanecarboxylic acid
• 英文别名: 3-Acetyl-cyclopentancarbonsaeure；3-Acetylcyclopentane-1-carboxylic acid
• CAS: 214531-78-9
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: AFIXJKKTUDGNLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 3-乙酰基环戊烷羧酸 生成 (Z)-3-acetylcyclopentanecarboxylate 、 (E)-3-acetylcyclopentanecarboxylate
  参考文献：
  名称：

  Sato, Masayuki; Abe, Yoshito; Takayama, Kazuhisa, Journal of Heterocyclic Chemistry, 1991, vol. 28, # 2, p. 241 - 252

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(3-butenyl)-2-methyl-4-oxo-1,5-dioxaspiro<5.5>undec-2-ene 在 水 作用下， 以 丙酮 、 乙腈 为溶剂， 反应 7.5h， 生成 3-乙酰基环戊烷羧酸
  参考文献：
  名称：

  Sato, Masayuki; Abe, Yoshito; Takayama, Kazuhisa, Journal of Heterocyclic Chemistry, 1991, vol. 28, # 2, p. 241 - 252

  摘要：

  DOI：

文献信息

• [EN] AMINOPYRIMIDINES AS SYK INHIBITORS<br/>[FR] AMINOPYRIMIDINES EN TANT QU'INHIBITEURS DE SYK
  申请人：MERCK SHARP & DOHME

  公开号：WO2012154519A1

  公开（公告）日：2012-11-15

  The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

  本发明提供了一种新型的嘧啶胺化合物，其化学式为I，它们是脾酪氨酸激酶的有效抑制剂，可用于治疗和预防由该酶介导的疾病，如哮喘、慢性阻塞性肺病、类风湿关节炎和癌症。
• Process for the preparation of bicyclic diketone salts
  申请人：Syngenta Participations AG

  公开号：EP1352890A1

  公开（公告）日：2003-10-15

  The present invention relates to a process for the preparation of bicyclic 1,3-diketone salts of formula I wherein R1, R2, R3 and R4 are each independently of the others hydrogen or C1-C4alkyl; A and E are each independently of the other C1-C2alkylene, which may be substituted once or up to four times by a C1-C4alkyl group, and M+ is an alkali metal ion, alkaline earth metal ion or ammonium ion, by oxidation of a compound of formula II to a compound of formula III and subsequent conversion to a compound of formula I either in the presence of a base and a catalytic amount of a cyanide or in the presence of an alkali metal alcoholate or alkaline earth metal alcoholate, and to novel bicyclic enol lactone intermediates of formula III for use in that process.

  本发明涉及一种制备式I的双环1,3-二酮盐的方法，其中R1、R2、R3和R4各自独立地是氢或C1-C4烷基；A和E各自独立地是C1-C2烷基，可以被C1-C4烷基取代一次或多达四次；M+是碱金属离子、碱土金属离子或铵离子，通过将式II的化合物氧化为式III的化合物，然后在碱和氰化物的催化剂或碱金属醇醚或碱土金属醇醚的存在下将其转化为式I的化合物，以及用于该过程的新型双环烯醇内酯中间体式III。
• [EN] PROCESS FOR THE PRODUCTION OF CYCLIC DIKETONES<br/>[FR] PROCEDE DE PRODUCTION DE DICETONES CYCLIQUES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2005105717A1

  公开（公告）日：2005-11-10

  The present invention relates to the preparation of compounds of formula (I); wherein the substituents are as defined in claim 1, by reacting a compound of formula (II); with a bromine or chlorine source to form a compound of formula (III); and subsequently treating that compound with water.

  本发明涉及通过将式（II）的化合物与溴或氯源反应形成式（III）的化合物，然后用水处理来制备式（I）化合物的方法。其中取代基如权利要求1中所定义。
• AMINOPYRIMIDINES AS SYK INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2706853B1

  公开（公告）日：2017-06-14
• COMPOUNDS
  申请人：The University of Sheffield

  公开号：US20210113534A1

  公开（公告）日：2021-04-22

  Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , X, X 1 , X 2 , X 3 , L 1 and n are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM 2 ). Also disclosed are the compounds for use in the treatment of diseases modulated AM 2 , including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.