1-{[(1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexyl]oxy}propan-2-ol | 404344-45-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-{[(1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexyl]oxy}propan-2-ol
• 英文别名: 1-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxypropan-2-ol
• CAS: 404344-45-2
• 化学式: C₁₃H₂₆O₂
• 分子量: 214.34
• InChiKey: YYCMDSULBAGVMH-IBSWDFHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHOD FOR PRODUCING 3-MENTHOXY PROPANOL AND COMPOSITIONS FOR IMPARTING COOLING SENSATION
  申请人：Takasago International Corporation

  公开号：US20140328771A1

  公开（公告）日：2014-11-06

  [Problem] The present invention provides: a composition for imparting a cooling sensation, which contains 3-menthoxy propanol; and a method for producing 3-menthoxy propanol with high selectivity and high yield using 3-menthoxy-1,2-epoxypropane as a starting material. [Solution] The present invention relates to: a method for producing 3-menthoxy propanol with high selectivity and high yield by performing catalytic hydrogenation of 3-menthoxy-1,2-epoxypropane in the presence of a heterogeneous metal catalyst such as a cobalt, a ruthenium catalyst or a nickel catalyst; and an excellent composition for imparting a cooling sensation, which contains a mixture of 3-menthoxy-1-propanol and 1-menthoxy-2-propanol.

  【问题】本发明提供了一种含有3-甲氧基丙醇的赋予冷感的组合物，以及使用3-甲氧基-1,2-环氧丙烷为原料制备高选择性和高产率的3-甲氧基丙醇的方法。 【解决方案】本发明涉及一种方法，通过在存在杂质金属催化剂（如钴、钌催化剂或镍催化剂）的情况下对3-甲氧基-1,2-环氧丙烷进行催化氢化，从而制备高选择性和高产率的3-甲氧基丙醇；以及一种优秀的赋予冷感的组合物，其含有3-甲氧基-1-丙醇和1-甲氧基-2-丙醇的混合物。
• METHOD FOR PRODUCING 3-MENTHOXY PROPANOL AND COMPOSITION FOR IMPARTING COOLING SENSATION
  申请人：Takasago International Corporation

  公开号：EP2772477A1

  公开（公告）日：2014-09-03

  [Problem] The present invention provides: a composition for imparting a cooling sensation, which contains 3-menthoxy propanol; and a method for producing 3-menthoxy propanol with high selectivity and high yield using 3-menthoxy-1,2-epoxypropane as a starting material. [Solution] The present invention relates to: a method for producing 3-menthoxy propanol with high selectivity and high yield by performing catalytic hydrogenation of 3-menthoxy-1,2-epoxypropane in the presence of a heterogeneous metal catalyst such as a cobalt, a ruthenium catalyst or a nickel catalyst; and an excellent composition for imparting a cooling sensation, which contains a mixture of 3-menthoxy-1-propanol and 1-menthoxy-2-propanol.

  [问题]本发明提供了：一种用于赋予冷却感的组合物，其中含有 3-薄荷氧基丙醇；以 3-薄荷氧基-1,2-环氧丙烷为起始原料，以高选择性和高产率生产 3-薄荷氧基丙醇的方法。 [解]本发明涉及：一种在异质金属催化剂（如钴催化剂、钌催化剂或镍催化剂）存在下，通过对 3-menthoxy-1,2-epoxypropane 进行催化氢化反应，生产具有高选择性和高产率的 3-menthoxy-丙醇的方法；以及一种具有冷却感的优良组合物，该组合物含有 3-menthoxy-1-丙醇和 1-menthoxy-2-丙醇的混合物。