3-氨基吡啶-2-羧酸甲酯 | 36052-27-4

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-氨基吡啶-2-羧酸甲酯
• 中文别名: 3-氨基吡啶-2-甲酸甲酯
• 英文名称: methyl 3-aminopicolinate
• 英文别名: methyl 3-aminopyridine-2-carboxylate；3-aminopyridine-2-carboxylic acid methyl ester
• CAS: 36052-27-4
• 化学式: C₇H₈N₂O₂
• 分子量: 152.153
• InChiKey: YQKTYFNLRUWQFV-UHFFFAOYSA-N

物化性质

• 沸点：
  317.3±22.0 °C(Predicted)
• 密度：
  1.238±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P280,P305+P351+P338,P310
• 危险性描述：
  H302,H315,H319,H332,H335
• 储存条件：
  2-8°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Methyl 3-aminopyridine-2-carboxylate
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Methyl 3-aminopyridine-2-carboxylate
CAS number: 36052-27-4

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H8N2O2
Molecular weight: 152.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-氨基吡啶-2-羧酸甲酯 在 N-氯代丁二酰亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以55%的产率得到methyl 3-amino-4,6-dichloro-pyridine-2-carboxylate
  参考文献：
  名称：

  3-ALKENYL-6-HALO-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES

  摘要：

  3-烯基-6-卤代-4-氨基吡啶甲酸及其衍生物是强效除草剂，具有广泛的杂草控制谱。

  公开号：

  US20120190548A1
• 作为产物：
  描述：

  2,3-吡啶二酰亚胺 在 sodium hydroxide 、 sodium hypobromide 作用下， 以 甲醇 为溶剂， 反应 2.5h， 生成 3-氨基吡啶-2-羧酸甲酯
  参考文献：
  名称：

  3-芳基-4-羟基喹啉-2（1H）-作为NMDA /甘氨酸部位拮抗剂的5-，6-，7-和8-氮杂类似物的合成和SAR。

  摘要：

  合成了3-芳基-4-羟基喹啉-2（1H）-one的一系列5-，6-，7-和8-氮杂类似物，并测定为NMDA /甘氨酸受体拮抗剂。这些拮抗剂的体外效能是通过在大鼠大脑皮膜中置换甘氨酸位点放射性配体[[（3）H] 5,7-dicholorokynurenic酸（[（3）H] DCKA）确定的。还使用表达克隆的NMDA受体（NR）1A / 2C亚基的非洲爪蟾卵母细胞中的电生理测定法测试了所选化合物的功能拮抗作用。在研究的5、6、7、8氮杂-3-芳基-4-羟基喹啉2（1H）-中，5-氮杂7-氯-4-羟基-3-（3-苯氧基苯基） ）quinolin-2-（1H）-one（13i）是最有效的拮抗剂，在[（3）H] DCKA结合中的IC（50）值为110 nM，在电生理学中的K（b）为11 nM分析。

  DOI：

  10.1016/s0968-0896(01)00115-8

文献信息

• Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy
  作者：Zhisong Wang、Yan Gao、Lei He、Shuhao Sun、Tingting Xia、Lu Hu、Licheng Yao、Liangliang Wang、Dan Li、Hui Shi、Xuebin Liao

  DOI：10.1021/acs.jmedchem.1c00179

  日期：2021.6.10

  Activation of the toll-like receptors 7 and 8 has emerged as a promising strategy for cancer immunotherapy. Herein, we report the design and synthesis of a series of pyrido[3,2-d]pyrimidine-based toll-like receptor 7/8 dual agonists that exhibited potent and near-equivalent agonistic activities toward TLR7 and TLR8. In vitro, compounds 24e and 25a significantly induced the secretion of IFN-α, IFN-γ

  Toll 样受体 7 和 8 的激活已成为癌症免疫治疗的一种有前途的策略。在此，我们报告了一系列基于吡啶并 [3,2 - d ] 嘧啶的 Toll 样受体 7/8 双激动剂的设计和合成，这些激动剂对 TLR7 和 TLR8 表现出强效且接近等效的激动活性。在体外，化合物24e和25a在人外周血单核细胞测定中显着诱导 IFN-α、IFN-γ、TNF-α、IL-1β、IL-12p40 和 IP-10 的分泌。在体内，化合物24e、24m和25a通过重塑肿瘤微环境显着抑制 CT26 荷瘤小鼠的肿瘤生长。此外，化合物24e，24m和25a显着提高了 PD-1/PD-L1 阻断的抗肿瘤活性。特别是，化合物24e与抗 PD-L1 抗体结合导致肿瘤完全消退。这些结果表明，TLR7/8 激动剂（24e、24m和25a）作为单药或与 PD-1/PD-L1 阻断剂联合用于癌症免疫治疗具有巨大潜力。
• [EN] INSECTICIDAL METHODS USING PYRIDINE COMPOUNDS<br/>[FR] PROCÉDÉS INSECTICIDES UTILISANT DES COMPOSÉS À BASE DE PYRIDINE
  申请人：BASF SE

  公开号：WO2011057942A1

  公开（公告）日：2011-05-19

  The present invention relates to new insecticidal methods of using compounds of formula (I) wherein A, E, G, M, Y, X, R1 and R2 are defined as in the description, and to their enantiomers, diastereomers and agriculturally and veterinary acceptable salts. The present invention relates to methods of administering and applying such Pyridine compounds of formula I for insecticidal use and purposes in agriculture and in the veterinary field. The invention relates also to new derivatives of Pyridine compounds of formula (I).

  本发明涉及使用式(I)化合物的新杀虫方法，其中A、E、G、M、Y、X、R1和R2的定义如描述中所述，以及它们的对映体、二对映体和农业和兽医可接受的盐。本发明涉及用于杀虫用途和农业以及兽医领域的目的的给药和应用此类吡啶化合物的方法。该发明还涉及式(I)吡啶化合物的新衍生物。
• SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF
  申请人：AJINOMOTO CO., LTD.

  公开号：US20150051395A1

  公开（公告）日：2015-02-19

  Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.

  提供的是具有特定化学结构的磺酰胺衍生物，在其末端有一个带有苯基或含杂原子的杂环基团作为取代基的磺酰胺基团，以及药用可接受的盐。这些化合物是具有卓越的α4整合素抑制作用的全新化合物。
• [EN] ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS ALLOSTÉRIQUES D'EGFR ET LEURS PROCÉDÉS D'UTILISATION
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2021096948A1

  公开（公告）日：2021-05-20

  The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

  披露涉及作为表皮生长因子受体（EGFR）变构抑制剂的化合物；包含这些化合物的药物组合物；以及治疗或预防激酶介导的疾病的方法，包括癌症和其他增殖性疾病。
• [EN] INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE<br/>[FR] INHIBITEURS DE LA SYNTHÈSE DES PHOSPHOLIPIDES ET PROCÉDÉS D'UTILISATION
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2021035031A1

  公开（公告）日：2021-02-25

  Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome, hyperlipidemia, infection and inflammation.

  甘油3-磷酸酰基转移酶（GPAT）的抑制剂已提供；以及在癌症治疗中的使用方法；以及治疗与代谢综合征、高脂血症、感染和炎症相关的疾病的方法。