| 1110702-93-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1110702-93-6
• 化学式: C₃₀H₄₆O₃Si
• 分子量: 482.779
• InChiKey: QMZUNXIJWCSVKJ-NETZRZHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.05
• 重原子数：
  34.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以99%的产率得到
  参考文献：
  名称：

  Asymmetric total synthesis of MK8383: the iron-mediated coupling reaction is the only effective method for the construction of the (Z)-trisubstituted side-chain alkene

  摘要：

  The first asymmetric total synthesis of MK8383 through the iron-mediated coupling reaction is described. in this total synthesis, the key step was clearly the stereoselective construction of the (Z)-trisubstituted side-chain alkene. Although this problem was seemingly easy to resolve, in fact it presented us an opportunity to evaluate the coupling reactions reported to date, and the iron-mediated coupling reaction was found to be the only effective method for the stereoselective construction of the (Z)-trisubstituted sidechain alkene. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.10.138
• 作为产物：
  描述：

  、 苯甲酸酐 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 以96%的产率得到
  参考文献：
  名称：

  Asymmetric total synthesis of MK8383: the iron-mediated coupling reaction is the only effective method for the construction of the (Z)-trisubstituted side-chain alkene

  摘要：

  The first asymmetric total synthesis of MK8383 through the iron-mediated coupling reaction is described. in this total synthesis, the key step was clearly the stereoselective construction of the (Z)-trisubstituted side-chain alkene. Although this problem was seemingly easy to resolve, in fact it presented us an opportunity to evaluate the coupling reactions reported to date, and the iron-mediated coupling reaction was found to be the only effective method for the stereoselective construction of the (Z)-trisubstituted sidechain alkene. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.10.138