N,N'-di(quinolin-3-yl)malonamide | 1161432-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N,N'-di(quinolin-3-yl)malonamide
• 英文别名: N,N'-di(quinolin-3-yl)propanediamide
• CAS: 1161432-94-5
• 化学式: C₂₁H₁₆N₄O₂
• 分子量: 356.384
• InChiKey: QZSQEJXMFLMFTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  84
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氨基喹啉 、 丙二酸二乙酯 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以46%的产率得到N,N'-di(quinolin-3-yl)malonamide
  参考文献：
  名称：

  Design and Synthesis of Bis-amide and Hydrazide-containing Derivatives of Malonic Acid as Potential HIV-1 Integrase Inhibitors

  摘要：

  HIV-1 整合酶（IN）是开发新型艾滋病治疗药物的一个极具吸引力的有效靶点。为了寻找新的 IN 抑制剂，我们设计并合成了三个系列的丙二酸双酰胺和含酰肼衍生物。我们进行了一项对接研究，探讨了标题化合物与 IN 活性位点上必需氨基酸的潜在相互作用。

  DOI：

  10.3390/molecules13102442

文献信息

• Combination methods of treating cancer
  申请人：Bacopoulos G. Nicholas

  公开号：US20070190022A1

  公开（公告）日：2007-08-16

  The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, in a first treatment procedure, and a second amount of an anti-cancer agent in a second treatment procedure. The first and second amounts together comprise a therapeutically effective amount. The effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.

  本发明涉及一种治疗癌症的方法，通过在第一次治疗过程中向需要治疗的对象给予一定量的组蛋白去乙酰化酶（HDAC）抑制剂或其药学上可接受的盐或水合物，以及在第二次治疗过程中给予一定量的抗癌剂。第一次和第二次给予的药量加起来构成治疗上有效的药量。HDAC抑制剂和抗癌剂的作用可能是加成或协同的。
• Methods of treating cancer with hdac inhibitors
  申请人：Bacopoulos G. Nicholas

  公开号：US20070060614A1

  公开（公告）日：2007-03-15

  The present invention relates to methods of treating cancers, e.g., mesothelioma or lymphoma. More specifically, the present invention relates to methods of treating mesothelioma or diffuse large B-cell lymphoma (DLBCL), by administration of pharmaceutical compositions comprising HDAC inhibitors, e.g., suberoylanilide hydroxamic acid (SAHA). The oral formulations of the pharmaceutical compositions have favorable pharmacokinetic profiles such as high bioavailability and surprisingly give rise to high blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.
• Design and Synthesis of Bis-amide and Hydrazide-containing Derivatives of Malonic Acid as Potential HIV-1 Integrase Inhibitors
  作者：Mario Sechi、Ugo Azzena、Maria Paola Delussu、Roberto Dallocchio、Alessandro Dessì、Alessia Cosseddu、Nicolino Pala、Nouri Neamati

  DOI：10.3390/molecules13102442

  日期：——

  HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active site.

  HIV-1 整合酶（IN）是开发新型艾滋病治疗药物的一个极具吸引力的有效靶点。为了寻找新的 IN 抑制剂，我们设计并合成了三个系列的丙二酸双酰胺和含酰肼衍生物。我们进行了一项对接研究，探讨了标题化合物与 IN 活性位点上必需氨基酸的潜在相互作用。