8-bromo-2,4-dimethoxyquinoline | 406204-87-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-bromo-2,4-dimethoxyquinoline
• CAS: 406204-87-3
• 化学式: C₁₁H₁₀BrNO₂
• 分子量: 268.11
• InChiKey: FSOAZBVRYMNADL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-bromo-2,4-dimethoxyquinoline 、 苯硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 48.0h， 以90%的产率得到2,4-Dimethoxy-8-phenyl-quinoline
  参考文献：
  名称：

  Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes

  摘要：

  2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode Haemonchus contortus, with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabendazole-resistant strains of H. contortus. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.07.044
• 作为产物：
  描述：

  2-溴苯胺 、 alkaline earth salt of/the/ methylsulfuric acid 在 三氯氧磷 作用下， 以 甲醇 为溶剂， 反应 53.0h， 生成 8-bromo-2,4-dimethoxyquinoline
  参考文献：
  名称：

  Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes

  摘要：

  2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode Haemonchus contortus, with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabendazole-resistant strains of H. contortus. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.07.044

文献信息

• [EN] ANTIPARASITIC COMPOUNDS<br/>[FR] COMPOSES ANTIPARASITES
  申请人：KING S COLLEGE LONDON

  公开号：WO2002026713A1

  公开（公告）日：2002-04-04

  Disclosed are antiparasitic compounds of Formulae (I, IA and IB). These compounds are useful in the manufacture of a pharmaceutical composition for the treatment or prophylaxis of infections caused by helminths or arthropod ectoparasites.