alpha-R-Lipoic acid choline ester | 1258491-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二硫杂环戊烷
• 英文名称: alpha-R-Lipoic acid choline ester
• 英文别名: 2-[5-[(3R)-dithiolan-3-yl]pentanoyloxy]ethyl-trimethylazanium
• CAS: 1258491-58-5
• 化学式: C13H26NO2S2+
• 分子量: 292.5
• InChiKey: BJNSJJXGLIMYAJ-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  76.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY SKIN DISEASES AND CANCER<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE MALADIES DE LA PEAU INFLAMMATOIRES ET DU CANCER
  申请人：CELLIX BIO PRIVATE LTD

  公开号：WO2019243970A1

  公开（公告）日：2019-12-26

  The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II formula III, formula IV, formula V, formula VI, formula VII, and formula VIII and the methods for the treatment of inflammatory skin diseases and cancer may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, nasal spray, oral solution, suspension, oral spray, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of facial hirsutism, GI Polyps, rosacea, acne, melanoma, psoriasis, dermatitis and cancer including gliomas, gastrointestinal polyps, anaplastic astrocytoma and metastatic cancers.

  本发明涉及化合物及其药学上可接受的多晶形、溶剂化物、对映体、立体异构体和水合物。其中，化合物包括公式I、公式II、公式III、公式IV、公式V、公式VI、公式VII和公式VIII。制备这些化合物的药物组合物可用于口服、颊粘膜、肛门、局部、经皮、经黏膜、含片、喷雾、静脉注射、口服溶液、鼻喷雾、口服悬浮液、口腔喷雾、颊粘膜层片剂、肌肉注射、糖浆或注射剂等途径治疗炎症性皮肤病和癌症。这些组合物可用于治疗面部多毛症、胃肠息肉、酒渣鼻、痤疮、黑色素瘤、牛皮癣、皮炎以及包括胶质瘤、胃肠息肉、间变性星形细胞瘤和转移性癌症在内的癌症。
• Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid
  申请人：Encore Health, LLC

  公开号：US20150246903A9

  公开（公告）日：2015-09-03

  Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

  公开了二硫化合物及其衍生物。这些药物对治疗眼部疾病，特别是老视和白内障，具有益处。
• Choline Esters
  申请人：Garner William

  公开号：US20100317725A1

  公开（公告）日：2010-12-16

  Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.

  提供了含有还原剂胆碱酯的化合物、配方和方法，特别是丙硫氨酸或其衍生物。这些化合物可以通过局部眼部途径给予，以治疗或预防氧化损伤。
• Dithiol Compounds, Derivatives, and Uses Therefor
  申请人：Encore Health, LLC

  公开号：US20160264545A1

  公开（公告）日：2016-09-15

  Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

  本发明公开了二硫化合物及其衍生物。这些药剂对于治疗眼部疾病，特别是老视和白内障非常有用。
• Method of treating presbyopia using dithiol compounds and their derivatives
  申请人：Encore Health, LLC

  公开号：US10039743B2

  公开（公告）日：2018-08-07

  Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

  本研究公开了二硫醇化合物及其衍生物。这些制剂可用于治疗眼部疾病，尤其是老花眼和白内障。