3-氯吖啶-9-胺 | 3407-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3-氯吖啶-9-胺
• 英文名称: 5-Amino-2-chloroacridin
• 英文别名: 9-Amino-3-chlor-acridin；3-chloro-acridin-9-ylamine；3-Chlor-acridin-9-ylamin；Acridine, 9-amino-3-chloro-；3-chloroacridin-9-amine
• CAS: 3407-98-5
• 化学式: C₁₃H₉ClN₂
• 分子量: 228.681
• InChiKey: IRSNBSGPKPZUDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  3-氯吖啶-9-胺 、 乙酸酐 生成 N-(3-chloro-acridin-9-yl)-diacetamide
  参考文献：
  名称：

  32.一些5-氨基ac啶的乙酰化

  摘要：

  DOI：

  10.1039/jr9460000115
• 作为产物：
  描述：

  3-氯-9(10H)-吖啶酮 在 三氯氧磷 作用下， 生成 3-氯吖啶-9-胺
  参考文献：
  名称：

  357. cr啶系列的化学治疗研究。第二部分 2-氨基，2：5-，2：7-和2：9-二氨基-啶

  摘要：

  DOI：

  10.1039/jr9360001614

文献信息

• Fluorescent N-alkylated acrylamide copolymers and optical pH sensors
  申请人：——

  公开号：US20010018217A1

  公开（公告）日：2001-08-30

  The invention relates to a polymer composition comprising pH-sensitive fluorescent dyes, to an ionic strength-independent optical sensor for pH value determination that contains the composition in the form of a membrane on a transparent support material, and to an optical process, according to the fluorescence method, that renders possible highly accurate pH value determination independently of the ionic strength of the test solution. The process is especially suitable for the determination of the pH value of physiological solutions, especially for the determination of the pH value of blood.

  本发明涉及一种包含对 pH 值敏感的荧光染料的聚合物组合物，涉及一种与离子强度无关的用于测定 pH 值的光学传感器，该传感器在透明支撑材料上以膜的形式包含该组合物，还涉及一种根据荧光方法的光学过程，该过程可实现与测试溶液的离子强度无关的高精度 pH 值测定。该工艺尤其适用于生理溶液 pH 值的测定，特别是血液 pH 值的测定。
• Inhibition of <i>Trypanosoma cruzi</i> Trypanothione Reductase by Acridines:  Kinetic Studies and Structure−Activity Relationships
  作者：Susanne Bonse、Christiane Santelli-Rouvier、Jacques Barbe、R. Luise Krauth-Siegel

  DOI：10.1021/jm990386s

  日期：1999.12.1

  Series of 9-amino and 9-thioacridines have been synthesized and studied as inhibitors of trypanothione reductase (TR) from Trypanosoma cruzi, the causative agent; of Chagas' disease. The compounds are structural analogues of the acridine drug mepacrine (quinacrine), which is a competitive inhibitor of the parasite enzyme, but not of human glutathione reductase, the closest related host enzyme. The 9-aminoacridines yielded apparent K-i values for competitive inhibition between 5 and 43 mu M. The most effective inhibitors were those with the methoxy and chlorine substituents of mepacrine and NH2 or NHCH(CH3)(CH2)(4)N(Et)(2) at C9. Detailed kinetic analyses revealed that in the case of 9-aminoacridines more than one inhibitor molecule can bind to the enzyme. In contrast, the 9-thioacridine derivatives inhibit TR with mixed-type kinetics. The kinetic data are discussed in light of the three-dimensional structure of the TR-mepacrine complex. The conclusion that structurally very similar acridine compounds can give rise to completely different inhibition patterns renders modelling studies and quantitative structure-activity relationships difficult.
• Albert; Gledhill, Journal of the Society of Chemical Industry, 1945, vol. 64, p. 169,170
  作者：Albert、Gledhill

  DOI：——

  日期：——
• Albert et al., 1937, vol. 10, p. 649,652
  作者：Albert et al.

  DOI：——

  日期：——
• Grigorowsky, Doklady Akademii Nauk SSSR, 1946, vol. 53, p. 229
  作者：Grigorowsky

  DOI：——

  日期：——