| 1204189-95-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1204189-95-6
• 化学式: C₃₆H₆₃N₃O₂₄
• 分子量: 921.902
• InChiKey: JAIBHNIQLJUDSX-ZECYHMTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9.1
• 重原子数：
  63.0
• 可旋转键数：
  21.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  438.12
• 氢给体数：
  16.0
• 氢受体数：
  24.0

反应信息

• 作为产物：
  描述：

  、 乙酸酐 在 水 、 sodium hydroxide 、 吡啶 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 40.0h， 以27 mg的产率得到
  参考文献：
  名称：

  Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays

  摘要：

  A library of 27 sialosides, including seventeen 2,3-linked and ten 2,6-linked glycans, has been prepared to construct a glycan array and used to profile the binding specificity of different influenza hemagglutinins (HA) subtypes, especially from the 2009 swine-originated H1N1 and seasonal influenza viruses. It was found that the HAs from the 2009 H1N1 and the seasonal Brisbane strain share similar binding profiles yet different binding affinities toward various alpha 2,6 sialosides. Analysis of the binding profiles of different HA subtypes indicate that a minimum set of 5 oligosaccharides can be used to differentiate influenza H1, H3, H5, H7, and H9 subtypes. In addition, the glycan array was used to profile the binding pattern of different influenza viruses. It was found that most binding patterns of viruses and HA proteins are similar and that glycosylation at Asn27 is essential for receptor binding.

  DOI：

  10.1021/ja104657b